Entity Details

Primary name SIR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6E7
EntryNameSIR4_HUMAN
FullNameNAD-dependent protein lipoamidase sirtuin-4, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT4

GO terms

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GOName
GO:0000820 regulation of glutamine family amino acid metabolic process
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006471 protein ADP-ribosylation
GO:0006541 glutamine metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007005 mitochondrion organization
GO:0008270 zinc ion binding
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0034983 peptidyl-lysine deacetylation
GO:0046322 negative regulation of fatty acid oxidation
GO:0046676 negative regulation of insulin secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0047708 biotinidase activity
GO:0061690 lipoamidase activity
GO:0070403 NAD+ binding
GO:0071456 cellular response to hypoxia
GO:0072350 tricarboxylic acid metabolic process
GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1904182 regulation of pyruvate dehydrogenase activity

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR026587 Sirtuin, class IIFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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