Entity Details

Primary name LRP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75197
EntryNameLRP5_HUMAN
FullNameLow-density lipoprotein receptor-related protein 5
TaxID9606
Evidenceevidence at protein level
Length1615
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesLRP5

GO terms

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GOName
GO:0001702 gastrulation with mouth forming second
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002076 osteoblast development
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006007 glucose catabolic process
GO:0006897 endocytosis
GO:0008203 cholesterol metabolic process
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009952 anterior/posterior pattern specification
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0017147 Wnt-protein binding
GO:0033690 positive regulation of osteoblast proliferation
GO:0035019 somatic stem cell population maintenance
GO:0035426 extracellular matrix-cell signaling
GO:0042074 cell migration involved in gastrulation
GO:0042632 cholesterol homeostasis
GO:0042733 embryonic digit morphogenesis
GO:0042813 Wnt-activated receptor activity
GO:0042981 regulation of apoptotic process
GO:0043235 receptor complex
GO:0043434 response to peptide hormone
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0048539 bone marrow development
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060033 anatomical structure regression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060612 adipose tissue development
GO:0060764 cell-cell signaling involved in mammary gland development
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061304 retinal blood vessel morphogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:0110135 Norrin signaling pathway
GO:1901998 toxin transport
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
GO:1990851 Wnt-Frizzled-LRP5/6 complex
GO:1990909 Wnt signalosome

Subcellular Location

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Subcellular Location
Endoplasmic reticulum
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000742 EGF-like domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR017049 Low density lipoprotein receptor-related protein 5/6FamilyFamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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