Entity Details

Primary name GABR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75899
EntryNameGABR2_HUMAN
FullNameGamma-aminobutyric acid type B receptor subunit 2
TaxID9606
Evidenceevidence at protein level
Length941
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesGABBR2

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0004965 G protein-coupled GABA receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 chemical synaptic transmission
GO:0038039 G protein-coupled receptor heterodimeric complex
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0046982 protein heterodimerization activity
GO:0150099 neuron-glial cell signaling
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1902710 GABA receptor complex

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000337 GPCR, family 3FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR002455 GPCR family 3, GABA-B receptorFamilyFamily
IPR002457 GPCR family 3, gamma-aminobutyric acid receptor, type B2FamilyFamily
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR041689 Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00181 BaclofenDrugbanksmall molecule
DB02530 gamma-Aminobutyric acidDrugbanksmall molecule
DB05010 SGS-742Drugbanksmall molecule
DB08891 ArbaclofenDrugbanksmall molecule
DB08892 Arbaclofen PlacarbilDrugbanksmall molecule