Entity Details

Primary name SIX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95343
EntryNameSIX3_HUMAN
FullNameHomeobox protein SIX3
TaxID9606
Evidenceevidence at protein level
Length332
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesSIX3

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 transcription corepressor binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001654 eye development
GO:0002070 epithelial cell maturation
GO:0002088 lens development in camera-type eye
GO:0003404 optic vesicle morphogenesis
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0007601 visual perception
GO:0009946 proximal/distal axis specification
GO:0014016 neuroblast differentiation
GO:0021537 telencephalon development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0042127 regulation of cell population proliferation
GO:0045665 negative regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0061074 regulation of neural retina development
GO:0070306 lens fiber cell differentiation
GO:0097402 neuroblast migration
GO:1901987 regulation of cell cycle phase transition
GO:1902692 regulation of neuroblast proliferation
GO:1902742 apoptotic process involved in development
GO:1990086 lens fiber cell apoptotic process
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000177 regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR031701 Homeobox protein SIX1, N-terminal SD domainDomainDomain
IPR032949 Homeobox protein SIX3/SIX6FamilyFamily

Diseases

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