Entity Details

Primary name OAS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00973
EntryNameOAS1_HUMAN
FullName2'-5'-oligoadenylate synthase 1
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesOAS1

GO terms

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GOName
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0006006 glucose metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009615 response to virus
GO:0016020 membrane
GO:0032728 positive regulation of interferon-beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035457 cellular response to interferon-alpha
GO:0035458 cellular response to interferon-beta
GO:0042593 glucose homeostasis
GO:0042742 defense response to bacterium
GO:0043129 surfactant homeostasis
GO:0045071 negative regulation of viral genome replication
GO:0046872 metal ion binding
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0060700 regulation of ribonuclease activity
GO:0070106 interleukin-27-mediated signaling pathway
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071659 negative regulation of IP-10 production
GO:0098586 cellular response to virus
GO:0140374 antiviral innate immune response
GO:1901857 positive regulation of cellular respiration
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Microsome
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR002934 Polymerase, nucleotidyl transferase domainDomainDomain
IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domainDomainDomain
IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved siteSiteConserved site
IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminalDomainDomain
IPR026774 2'-5'-oligoadenylate synthaseFamilyFamily
IPR043518 2-5-oligoadenylate synthetase, N-terminal conserved siteSiteConserved site
IPR043519 Nucleotidyltransferase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02987 Cysteine-S-acetamideDrugbanksmall molecule