Entity Details

Primary name TIMP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01033
EntryNameTIMP1_HUMAN
FullNameMetalloproteinase inhibitor 1
TaxID9606
Evidenceevidence at protein level
Length207
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTIMP1

GO terms

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GOName
GO:0001775 cell activation
GO:0002020 protease binding
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0002576 platelet degranulation
GO:0004857 enzyme inhibitor activity
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007568 aging
GO:0008083 growth factor activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030414 peptidase inhibitor activity
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0034097 response to cytokine
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043434 response to peptide hormone
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051216 cartilage development
GO:0070062 extracellular exosome
GO:0071492 cellular response to UV-A
GO:1901164 negative regulation of trophoblast cell migration
GO:1905049 negative regulation of metallopeptidase activity
GO:2001044 regulation of integrin-mediated signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR001820 Protease inhibitor I35 (TIMP)FamilyFamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015611 Metalloproteinase inhibitor 1FamilyFamily
IPR027465 Proteinase inhibitor I35b (TIMP), C-terminalFamilyHomologous superfamily
IPR030490 Tissue inhibitor of metalloproteinase, conserved siteSiteConserved site

Diseases

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