Entity Details

Primary name PTHY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01270
EntryNamePTHY_HUMAN
FullNameParathyroid hormone
TaxID9606
Evidenceevidence at protein level
Length115
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPTH

GO terms

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GOName
GO:0001501 skeletal system development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007266 Rho protein signal transduction
GO:0007267 cell-cell signaling
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010960 magnesium ion homeostasis
GO:0030501 positive regulation of bone mineralization
GO:0031856 parathyroid hormone receptor binding
GO:0031857 type 1 parathyroid hormone receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0033280 response to vitamin D
GO:0034645 cellular macromolecule biosynthetic process
GO:0042493 response to drug
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046058 cAMP metabolic process
GO:0046326 positive regulation of glucose import
GO:0046686 response to cadmium ion
GO:0047485 protein N-terminus binding
GO:0048018 receptor ligand activity
GO:0048873 homeostasis of number of cells within a tissue
GO:0051428 peptide hormone receptor binding
GO:0055062 phosphate ion homeostasis
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0071107 response to parathyroid hormone
GO:0071774 response to fibroblast growth factor
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0090290 positive regulation of osteoclast proliferation
GO:1900158 negative regulation of bone mineralization involved in bone maturation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001415 Parathyroid hormone/parathyroid hormone-related proteinFamilyFamily
IPR003625 Parathyroid hormoneFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04419 D-norleucineDrugbanksmall molecule
DB05883 ABX-PTHDrugbankbiotech

Interactions

8 interactions