Entity Details

Primary name CSF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04141
EntryNameCSF2_HUMAN
FullNameGranulocyte-macrophage colony-stimulating factor
TaxID9606
Evidenceevidence at protein level
Length144
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesCSF2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001821 histamine secretion
GO:0001892 embryonic placenta development
GO:0005125 cytokine activity
GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006955 immune response
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0019221 cytokine-mediated signaling pathway
GO:0030099 myeloid cell differentiation
GO:0030223 neutrophil differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0032747 positive regulation of interleukin-23 production
GO:0034021 response to silicon dioxide
GO:0034405 response to fluid shear stress
GO:0042045 epithelial fluid transport
GO:0042116 macrophage activation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043011 myeloid dendritic cell differentiation
GO:0043231 intracellular membrane-bounded organelle
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045637 regulation of myeloid cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071222 cellular response to lipopolysaccharide
GO:0071803 positive regulation of podosome assembly
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097028 dendritic cell differentiation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000773 Granulocyte-macrophage colony-stimulating factorFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05194 KB002Drugbanksmall molecule