Entity Details

Primary name ACM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11229
EntryNameACM1_HUMAN
FullNameMuscarinic acetylcholine receptor M1
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCHRM1

GO terms

Show/Hide Table
GOName
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007399 nervous system development
GO:0016020 membrane
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0040012 regulation of locomotion
GO:0043270 positive regulation of ion transport
GO:0043679 axon terminus
GO:0045202 synapse
GO:0046541 saliva secretion
GO:0050890 cognition
GO:0060251 regulation of glial cell proliferation
GO:0090316 positive regulation of intracellular protein transport
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0098981 cholinergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000995 Muscarinic acetylcholine receptor familyFamilyFamily
IPR002228 Muscarinic acetylcholine receptor M1FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00185 CevimelineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00202 SuccinylcholineDrugbanksmall molecule
DB00209 TrospiumDrugbanksmall molecule
DB00219 OxyphenoniumDrugbanksmall molecule
DB00245 BenzatropineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00332 IpratropiumDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00340 MetixeneDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00354 BuclizineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00366 DoxylamineDrugbanksmall molecule
DB00376 TrihexyphenidylDrugbanksmall molecule
DB00383 OxyphencyclimineDrugbanksmall molecule
DB00387 ProcyclidineDrugbanksmall molecule
DB00392 ProfenamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00424 HyoscyamineDrugbanksmall molecule
DB00434 CyproheptadineDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00462 Methscopolamine bromideDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00483 Gallamine triethiodideDrugbanksmall molecule
DB00496 DarifenacinDrugbanksmall molecule
DB00505 TridihexethylDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00517 Anisotropine methylbromideDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00670 PirenzepineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00725 Homatropine methylbromideDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00747 ScopolamineDrugbanksmall molecule
DB00767 BenzquinamideDrugbanksmall molecule
DB00771 ClidiniumDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00782 PropanthelineDrugbanksmall molecule
DB00804 DicyclomineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00809 TropicamideDrugbanksmall molecule
DB00810 BiperidenDrugbanksmall molecule
DB00835 BrompheniramineDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00940 MethanthelineDrugbanksmall molecule
DB00942 CycrimineDrugbanksmall molecule
DB00979 CyclopentolateDrugbanksmall molecule
DB00986 GlycopyrroniumDrugbanksmall molecule
DB01019 BethanecholDrugbanksmall molecule
DB01036 TolterodineDrugbanksmall molecule
DB01062 OxybutyninDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01085 PilocarpineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01148 FlavoxateDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01231 DiphenidolDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01409 TiotropiumDrugbanksmall molecule
DB01591 SolifenacinDrugbanksmall molecule
DB01618 MolindoneDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB04365 ArecolineDrugbanksmall molecule
DB04843 MepenzolateDrugbanksmall molecule
DB05152 NGX267Drugbanksmall molecule
DB05752 ALKS 27Drugbanksmall molecule
DB05766 ACP-104Drugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06702 FesoterodineDrugbanksmall molecule
DB06787 HexocycliumDrugbanksmall molecule
DB08897 AclidiniumDrugbanksmall molecule
DB09076 UmeclidiniumDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09262 ImidafenacinDrugbanksmall molecule
DB11156 PyrantelDrugbanksmall molecule
DB11181 HomatropineDrugbanksmall molecule
DB11235 ThonzylamineDrugbanksmall molecule
DB11855 RevefenacinDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13581 RociverineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

5 interactions