Entity Details

Primary name NFH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12036
EntryNameNFH_HUMAN
FullNameNeurofilament heavy polypeptide
TaxID9606
Evidenceevidence at protein level
Length1026
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesNEFH

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0005200 structural constituent of cytoskeleton
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005883 neurofilament
GO:0007409 axonogenesis
GO:0008017 microtubule binding
GO:0014069 postsynaptic density
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030031 cell projection assembly
GO:0030424 axon
GO:0030674 protein-macromolecule adaptor activity
GO:0033693 neurofilament bundle assembly
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0060052 neurofilament cytoskeleton organization
GO:0061564 axon development
GO:0070840 dynein complex binding
GO:0097418 neurofibrillary tangle
GO:0098685 Schaffer collateral - CA1 synapse
GO:0099160 postsynaptic intermediate filament cytoskeleton
GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
GO:1902513 regulation of organelle transport along microtubule
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR010790 Repeat of unknown function DUF1388RepeatRepeat
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR033183 Neurofilament heavy polypeptideFamilyFamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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