Entity Details

Primary name ADRB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13945
EntryNameADRB3_HUMAN
FullNameBeta-3 adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length408
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesADRB3

GO terms

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GOName
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004939 beta-adrenergic receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005975 carbohydrate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0015052 beta3-adrenergic receptor activity
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0051379 epinephrine binding
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000681 Beta 3 adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00217 BethanidineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00785 CryptenamineDrugbanksmall molecule
DB00866 AlprenololDrugbanksmall molecule
DB00871 TerbutalineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00960 PindololDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB01001 SalbutamolDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01102 ArbutamineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01288 FenoterolDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01365 MephentermineDrugbanksmall molecule
DB01407 ClenbuterolDrugbanksmall molecule
DB01580 OxprenololDrugbanksmall molecule
DB04846 CeliprololDrugbanksmall molecule
DB04861 NebivololDrugbanksmall molecule
DB05395 AmibegronDrugbanksmall molecule
DB06190 SolabegronDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06726 BufuralolDrugbanksmall molecule
DB08807 BopindololDrugbanksmall molecule
DB08808 BupranololDrugbanksmall molecule
DB08893 MirabegronDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14895 VibegronDrugbanksmall molecule