Entity Details

Primary name AK1A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14550
EntryNameAK1A1_HUMAN
FullNameAldo-keto reductase family 1 member A1
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1A1

GO terms

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GOName
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0009055 electron transfer activity
GO:0016324 apical plasma membrane
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0045202 synapse
GO:0046185 aldehyde catabolic process
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0047939 L-glucuronate reductase activity
GO:0047941 glucuronolactone reductase activity
GO:0047956 glycerol dehydrogenase [NADP+] activity
GO:0070062 extracellular exosome
GO:0110095 cellular detoxification of aldehyde
GO:1901687 glutathione derivative biosynthetic process
GO:1990002 methylglyoxal reductase (NADPH-dependent, acetol producing)

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044481 Aldo-keto reductase family 1 member A1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB02383 TolrestatDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB08904 Certolizumab pegolDrugbankbiotech
DB09130 CopperDrugbanksmall molecule