Entity Details

Primary name ALDR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15121
EntryNameALDR_HUMAN
FullNameAldo-keto reductase family 1 member B1
TaxID9606
Evidenceevidence at protein level
Length316
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1B1

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001758 retinal dehydrogenase activity
GO:0001894 tissue homeostasis
GO:0002070 epithelial cell maturation
GO:0003091 renal water homeostasis
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005975 carbohydrate metabolic process
GO:0006061 sorbitol biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0009055 electron transfer activity
GO:0009414 response to water deprivation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032838 plasma membrane bounded cell projection cytoplasm
GO:0033010 paranodal junction
GO:0035809 regulation of urine volume
GO:0036130 prostaglandin H2 endoperoxidase reductase activity
GO:0042415 norepinephrine metabolic process
GO:0042629 mast cell granule
GO:0043066 negative regulation of apoptotic process
GO:0043220 Schmidt-Lanterman incisure
GO:0043795 glyceraldehyde oxidoreductase activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0046370 fructose biosynthetic process
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0047956 glycerol dehydrogenase [NADP+] activity
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0052650 NADP-retinol dehydrogenase activity
GO:0060135 maternal process involved in female pregnancy
GO:0070062 extracellular exosome
GO:0071475 cellular hyperosmotic salinity response
GO:0072061 inner medullary collecting duct development
GO:0072205 metanephric collecting duct development
GO:0097066 response to thyroid hormone
GO:0097238 cellular response to methylglyoxal
GO:0097454 Schwann cell microvillus
GO:1901653 cellular response to peptide

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00605 SulindacDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01689 Inhibitor Idd 384Drugbanksmall molecule
DB02007 alpha-D-glucose 6-phosphateDrugbanksmall molecule
DB02020 AlrestatinDrugbanksmall molecule
DB02021 FidarestatDrugbanksmall molecule
DB02101 (S,R)-fidarestatDrugbanksmall molecule
DB02132 ZenarestatDrugbanksmall molecule
DB02383 TolrestatDrugbanksmall molecule
DB02518 N-AcetylalanineDrugbanksmall molecule
DB02712 SorbinilDrugbanksmall molecule
DB02834 IDD552Drugbanksmall molecule
DB02994 Cacodylic acidDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB04272 Citric acidDrugbanksmall molecule
DB05327 RanirestatDrugbanksmall molecule
DB05383 PimagedineDrugbanksmall molecule
DB05533 QR-333Drugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB07028 (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACIDDrugbanksmall molecule
DB07030 (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACIDDrugbanksmall molecule
DB07063 LidorestatDrugbanksmall molecule
DB07093 {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACIDDrugbanksmall molecule
DB07139 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acidDrugbanksmall molecule
DB07187 CP-744809Drugbanksmall molecule
DB07450 (R)-minalrestatDrugbanksmall molecule
DB07498 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACIDDrugbanksmall molecule
DB07999 {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACIDDrugbanksmall molecule
DB08000 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDEDrugbanksmall molecule
DB08084 IDD594Drugbanksmall molecule
DB08098 {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acidDrugbanksmall molecule
DB08449 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acidDrugbanksmall molecule
DB08772 ZopolrestatDrugbanksmall molecule
DB11859 BrexanoloneDrugbanksmall molecule