Entity Details

Primary name TPH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17752
EntryNameTPH1_HUMAN
FullNameTryptophan 5-hydroxylase 1
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesTPH1

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0005829 cytosol
GO:0007623 circadian rhythm
GO:0009072 aromatic amino acid family metabolic process
GO:0030279 negative regulation of ossification
GO:0035902 response to immobilization stress
GO:0042427 serotonin biosynthetic process
GO:0043005 neuron projection
GO:0045600 positive regulation of fat cell differentiation
GO:0046219 indolalkylamine biosynthetic process
GO:0046849 bone remodeling
GO:0060749 mammary gland alveolus development
GO:1900046 regulation of hemostasis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001273 Aromatic amino acid hydroxylaseFamilyFamily
IPR002912 ACT domainDomainDomain
IPR005963 Tryptophan 5-monooxygenaseFamilyFamily
IPR018301 Aromatic amino acid hydroxylase, iron/copper binding siteSiteBinding site
IPR019773 Tyrosine 3-monooxygenase-likeFamilyFamily
IPR019774 Aromatic amino acid hydroxylase, C-terminalDomainDomain
IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036951 Aromatic amino acid hydroxylase superfamilyFamilyHomologous superfamily
IPR041904 Tryptophan 5-hydroxylase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00150 TryptophanDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB05199 LX1031Drugbanksmall molecule
DB12095 Telotristat ethylDrugbanksmall molecule