Entity Details

Primary name RO52_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19474
EntryNameRO52_HUMAN
FullNameE3 ubiquitin-protein ligase TRIM21
TaxID9606
Evidenceevidence at protein level
Length475
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTRIM21

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000932 P-body
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0006513 protein monoubiquitination
GO:0007049 cell cycle
GO:0008270 zinc ion binding
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0016567 protein ubiquitination
GO:0019901 protein kinase binding
GO:0031410 cytoplasmic vesicle
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032092 positive regulation of protein binding
GO:0032479 regulation of type I interferon production
GO:0032880 regulation of protein localization
GO:0032897 negative regulation of viral transcription
GO:0034341 response to interferon-gamma
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045787 positive regulation of cell cycle
GO:0045824 negative regulation of innate immune response
GO:0046596 regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:0090086 negative regulation of protein deubiquitination
GO:1902187 negative regulation of viral release from host cell
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003613 U box domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR006574 SPRY-associatedDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR020457 Zinc finger, B-box, chordataDomainDomain
IPR035831 TRIM21, PRY/SPRY domainDomainDomain
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
RO52_HUMAN1433Z_HUMANBioGRID, HPRD, MINT15324660 29673441 details
RO52_HUMANNIF3L_HUMANBioGRID, HPRD, IntAct16189514 details
RO52_HUMANUBP4_HUMANBioGRID, HPRD, IntAct11461834 16403452 16472766 23105109 details
RO52_HUMANTNNI3_HUMANIntAct11461834 details
RO52_HUMANEF1D_HUMANIntAct11461834 details
RO52_HUMANMLP3A_HUMANBioGRID, IntAct20562859 26347139 details
RO52_HUMANMLP3B_HUMANBioGRID, IntAct20562859 26347139 details
RO52_HUMANGBRL2_HUMANBioGRID, IntAct20562859 26347139 details
RO52_HUMANGBRL1_HUMANBioGRID, IntAct20562859 26347139 details
RO52_HUMANAPC_HUMANBioGRID, IntAct20936779 29045831 details
RO52_HUMANTRI39_HUMANBioGRID, IntAct22493164 25416956 32296183 details
RO52_HUMANRN111_HUMANBioGRID, IntAct22493164 details
RO52_HUMANMAT1_HUMANBioGRID, IntAct22493164 details
RO52_HUMANHOIL1_HUMANBioGRID, IntAct22493164 details
RO52_HUMANDZIP3_HUMANBioGRID, IntAct22493164 details
RO52_HUMANTRI27_HUMANBioGRID, IntAct22493164 details
RO52_HUMANTRIM8_HUMANBioGRID, IntAct22493164 details
RO52_HUMANRO52_HUMANBioGRID, HPRD, IntAct11331580 15916807 16297862 16403452 17156811 18022694 21045130 22493164 22829933 25416956 29667579 31160341 32051585 32296183 32796032 details
RO52_HUMANGRAP_HUMANBioGRID, IntAct25416956 32296183 details
RO52_HUMANTHIOM_HUMANBioGRID, IntAct25416956 32296183 details
RO52_HUMANUBP15_HUMANBioGRID, IntAct23105109 25416956 details
RO52_HUMANTRIM3_HUMANBioGRID, IntAct32296183 details
RO52_HUMANTENS4_HUMANBioGRID, IntAct32296183 details
RO52_HUMANVP9D1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANECHP_HUMANBioGRID, IntAct32296183 details
RO52_HUMANT11L1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANCWC25_HUMANBioGRID, IntAct32296183 details
RO52_HUMANFHOD1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANEXOC8_HUMANBioGRID, IntAct32296183 details
RO52_HUMANIGFN1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANXAF1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANDMAP1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANGMCL1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANZBT16_HUMANBioGRID, IntAct32296183 details
RO52_HUMANYJU2_HUMANBioGRID, IntAct32296183 details
RO52_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
RO52_HUMANLX15B_HUMANBioGRID, IntAct32296183 details
RO52_HUMANCBX4_HUMANBioGRID, IntAct32296183 details
RO52_HUMANEGLN_HUMANBioGRID, UniProt31540324 details
RO52_HUMANDCTN1_HUMANIntAct32814053 details
RO52_HUMANPRKN_HUMANIntAct32814053 details
RO52_HUMANUCHL1_HUMANIntAct32814053 details
RO52_HUMANRNF11_HUMANIntAct32814053 details
RO52_HUMANSYUA_HUMANIntAct32814053 details
RO52_HUMANHD_HUMANIntAct32814053 details
RO52_HUMANIRF8_HUMANBioGRID17579016 details
RO52_HUMANSKP2_HUMANBioGRID16880511 details
RO52_HUMANCUL1_HUMANBioGRID16880511 details
RO52_HUMANFBW1B_HUMANBioGRID16880511 details
RO52_HUMANIRF3_HUMANBioGRID18641315 19265157 22479513 details
RO52_HUMANFADD_HUMANBioGRID21183682 details
RO52_HUMANIKKB_HUMANBioGRID19675099 29667579 details
RO52_HUMANDRB1_HUMANBioGRID18022694 details
RO52_HUMANSQSTM_HUMANBioGRID19201866 26043024 26347139 26942676 31852783 details
RO52_HUMANDAXX_HUMANBioGRID20697732 details
RO52_HUMANC8AP2_HUMANBioGRID20697732 details
RO52_HUMANTRIM5_HUMANBioGRID16775307 details
RO52_HUMANDCP2_HUMANBioGRID18361920 details
RO52_HUMANUB2D1_HUMANBioGRID17579016 21045130 details
RO52_HUMANUBE2H_HUMANBioGRID16472766 details
RO52_HUMANUB2D2_HUMANBioGRID16297862 16403452 16472766 19675099 details
RO52_HUMANUB2L3_HUMANBioGRID16472766 details
RO52_HUMANUBE2C_HUMANBioGRID16472766 details
RO52_HUMANUB2R1_HUMANBioGRID16472766 details
RO52_HUMANUBP2_HUMANBioGRID23105109 details
RO52_HUMANUBC_HUMANBioGRID23455675 details
RO52_HUMANUBC9_HUMANBioGRID25416956 32296183 details
RO52_HUMANIRF5_HUMANBioGRID25084355 details
RO52_HUMANMLP3C_HUMANBioGRID26347139 details
RO52_HUMANGBRAP_HUMANBioGRID26347139 details
RO52_HUMANCALR_HUMANBioGRID8666824 details
RO52_HUMANLFG2_HUMANBioGRID26398169 details
RO52_HUMANPFKAP_HUMANBioGRID29038421 details
RO52_HUMANSNAI1_HUMANBioGRID29331416 30502437 31622717 details
RO52_HUMANTBK1_HUMANBioGRID29667579 details
RO52_HUMANUB2E1_HUMANBioGRID31160341 details
RO52_HUMANSAMH1_HUMANBioGRID31797533 details
RO52_HUMANSETD7_HUMANBioGRID32102992 details
RO52_HUMANUBE2N_HUMANBioGRID, IntAct25260751 29667579 details
RO52_HUMANCEP63_HUMANIntAct31413325 details
RO52_HUMANNCOA1_HUMANBioGRID11971985 details
RO52_HUMANNCOA3_HUMANBioGRID11971985 16051665 details
RO52_HUMANSKP1_HUMANBioGRID16880511 details
RO52_HUMANCDN1B_HUMANBioGRID16880511 details
RO52_HUMANHDAC1_HUMANBioGRID20585571 details
RO52_HUMANIRF7_HUMANBioGRID20668674 details
RO52_HUMANFOG1_HUMANBioGRID17118455 details
RO52_HUMANCD52_HUMANBioGRID17118455 details
RO52_HUMANFCG2A_HUMANBioGRID17118455 details
RO52_HUMANRO60_HUMANBioGRID, HPRD10785401 11251884 details
RO52_HUMANULK1_HUMANBioGRID26347139 details
RO52_HUMANBECN1_HUMANBioGRID26347139 details
RO52_HUMANGAN_HUMANBioGRID26460568 details
RO52_HUMANANM5_HUMANBioGRID26658161 details
RO52_HUMANIN35_HUMANBioGRID26342464 details
RO52_HUMANNMI_HUMANBioGRID26342464 details
RO52_HUMANGUAA_HUMANBioGRID24462112 32005234 details
RO52_HUMANBAG6_HUMANBioGRID24981174 details
RO52_HUMANHDAC6_HUMANBioGRID26643866 32796032 details
RO52_HUMANPAWR_HUMANBioGRID27830973 details
RO52_HUMANK1C17_HUMANBioGRID29859926 details
RO52_HUMANMAVS_HUMANBioGRID29743353 details
RO52_HUMANPTMA_HUMANBioGRID30719818 details
RO52_HUMANELAV1_HUMANBioGRID31103853 32678213 details
RO52_HUMANARAF_HUMANBioGRID29777862 details
RO52_HUMANPHB_HUMANBioGRID30886235 details
RO52_HUMANIF16_HUMANBioGRID31665637 33061806 details
RO52_HUMANSPB5_HUMANBioGRID32005234 details
RO52_HUMANPO2F1_HUMANBioGRID27465491 details
RO52_HUMANTRIB2_HUMANBioGRID32913538 details