Entity Details

Primary name NCF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19878
EntryNameNCF2_HUMAN
FullNameNeutrophil cytosol factor 2
TaxID9606
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesNCF2

GO terms

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GOName
GO:0001669 acrosomal vesicle
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005829 cytosol
GO:0006801 superoxide metabolic process
GO:0006909 phagocytosis
GO:0006968 cellular defense response
GO:0008022 protein C-terminus binding
GO:0009055 electron transfer activity
GO:0016020 membrane
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0031267 small GTPase binding
GO:0032010 phagolysosome
GO:0034599 cellular response to oxidative stress
GO:0042554 superoxide anion generation
GO:0043020 NADPH oxidase complex
GO:0045087 innate immune response
GO:0045454 cell redox homeostasis
GO:0045730 respiratory burst
GO:0048010 vascular endothelial growth factor receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR034885 Neutrophil cytosol factor 2, PB1 domainDomainDomain
IPR034889 Neutrophil cytosol factor 2FamilyFamily
IPR035546 Neutrophil cytosol factor 2, SH3 domain 1DomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule

Interactions

22 interactions

InteractorPartnerSourcesPublicationsLink
NCF2_HUMANNCF4_HUMANBioGRID, HPRD, IntAct, MINT10486263 10672014 11483497 11796733 11893732 12813044 12887891 16297854 16782902 9083043 details
NCF2_HUMANCDC42_HUMANBioGRID, HPRD, MINT11090627 7738010 9642115 details
NCF2_HUMANRAC1_HUMANBioGRID, HPRD, IntAct, MINT11090627 11896062 25301945 25416956 7738010 8036496 9255350 9624165 9642115 details
NCF2_HUMANRAC2_HUMANBioGRID, HPRD, MINT11090627 9624165 9642115 details
NCF2_HUMANNCF1_HUMANBioGRID, HPRD, IntAct, MINT10486263 11248021 11733522 11796733 11893732 12169629 15657040 16052631 16297854 16782902 19129478 32296183 7938008 9121467 details
NCF2_HUMANKIFA3_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 26871637 31515488 32296183 details
NCF2_HUMANGOGA2_HUMANBioGRID, IntAct25416956 25910212 26871637 details
NCF2_HUMANKPCD_HUMANIntAct15591124 details
NCF2_HUMANPRDX6_HUMANBioGRID, HPRD12121978 details
NCF2_HUMANCY24A_HUMANBioGRID, HPRD11248021 11733522 11893732 11917128 details
NCF2_HUMANSYTL1_HUMANBioGRID, HPRD11278853 details
NCF2_HUMANPRKDC_HUMANBioGRID9914162 details
NCF2_HUMANS10A8_HUMANBioGRID, HPRD15642721 details
NCF2_HUMANS10A9_HUMANBioGRID15642721 details
NCF2_HUMANPA24A_HUMANBioGRID16844764 18765662 details
NCF2_HUMANAKT1_HUMANBioGRID12515553 details
NCF2_HUMANCY24B_HUMANBioGRID, HPRD11248021 11893732 11917128 15260500 details
NCF2_HUMANGNAI2_HUMANBioGRID, MINT16782902 details
NCF2_HUMANGBB1_HUMANBioGRID, MINT16782902 details
NCF2_HUMANTRAF4_HUMANBioGRID16052631 details
NCF2_HUMANGNAI1_HUMANBioGRID16782902 details
NCF2_HUMANGNAI3_HUMANBioGRID16782902 details