Entity Details

Primary name SDHL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20132
EntryNameSDHL_HUMAN
FullNameL-serine dehydratase/L-threonine deaminase
TaxID9606
Evidenceevidence at protein level
Length328
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesSDS

GO terms

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GOName
GO:0003941 L-serine ammonia-lyase activity
GO:0004794 L-threonine ammonia-lyase activity
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006094 gluconeogenesis
GO:0006565 L-serine catabolic process
GO:0006567 threonine catabolic process
GO:0009097 isoleucine biosynthetic process
GO:0019518 L-threonine catabolic process to glycine
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0042866 pyruvate biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding siteSiteBinding site
IPR001926 Pyridoxal-phosphate dependent enzymeDomainDomain
IPR036052 Tryptophan synthase beta subunit-like PLP-dependent enzymeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00133 SerineDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SDHL_HUMANDDI1_HUMANBioGRID, IntAct32296183 details
SDHL_HUMANHGS_HUMANBioGRID, IntAct32296183 details
SDHL_HUMANTGM7_HUMANBioGRID, IntAct32296183 details