Entity Details

Primary name CNR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21554
EntryNameCNR1_HUMAN
FullNameCannabinoid receptor 1
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesCNR1

GO terms

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GOName
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004949 cannabinoid receptor activity
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007413 axonal fasciculation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007613 memory
GO:0010976 positive regulation of neuron projection development
GO:0014063 negative regulation of serotonin secretion
GO:0015629 actin cytoskeleton
GO:0019222 regulation of metabolic process
GO:0019233 sensory perception of pain
GO:0030426 growth cone
GO:0031622 positive regulation of fever generation
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032496 response to lipopolysaccharide
GO:0032592 integral component of mitochondrial membrane
GO:0033004 negative regulation of mast cell activation
GO:0033602 negative regulation of dopamine secretion
GO:0035094 response to nicotine
GO:0038171 cannabinoid signaling pathway
GO:0042220 response to cocaine
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045759 negative regulation of action potential
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0050796 regulation of insulin secretion
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0060259 regulation of feeding behavior
GO:0060405 regulation of penile erection
GO:0098921 retrograde trans-synaptic signaling by endocannabinoid
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Membrane raft
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000810 Cannabinoid receptor type 1FamilyFamily
IPR002230 Cannabinoid receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Disease IDSourceNameDescription
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. The protein represented in this entry may be involved in disease pathogenesis. May contribute to the development of diet-induced obesity and several obesity-associated features, such as dyslipidemia and liver steatosis, regulating peripheral lipogenesis, energy expenditure and feeding behavior. CNR1 inverse agonists have been shown to reduce body weight and improve metabolic abnormalities in obese subjects, although adverse neuropsychiatric effects, including anxiety, irritability, and depressed mood, halted their therapeutic development (PubMed:18177726). In obese mice, peripherally restricted CNR1 inverse agonists have been shown to normalize metabolic abnormalities, including insulin resistance and fatty liver, and to reverse leptin resistance.

Drugs

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DrugNameSourceType
DB00470 DronabinolDrugbanksmall molecule
DB00486 NabiloneDrugbanksmall molecule
DB02955 Ricinoleic AcidDrugbanksmall molecule
DB05077 SLV319Drugbanksmall molecule
DB05201 V24343Drugbanksmall molecule
DB05750 AVE-1625Drugbanksmall molecule
DB06155 RimonabantDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB11745 OtenabantDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule