Entity Details

Primary name KCNA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22460
EntryNameKCNA5_HUMAN
FullNamePotassium voltage-gated channel subfamily A member 5
TaxID9606
Evidenceevidence at protein level
Length613
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesKCNA5

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005102 signaling receptor binding
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006813 potassium ion transport
GO:0007219 Notch signaling pathway
GO:0008076 voltage-gated potassium channel complex
GO:0009612 response to mechanical stimulus
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0014704 intercalated disc
GO:0015271 outward rectifier potassium channel activity
GO:0016021 integral component of membrane
GO:0019229 regulation of vasoconstriction
GO:0019901 protein kinase binding
GO:0030018 Z disc
GO:0034705 potassium channel complex
GO:0042391 regulation of membrane potential
GO:0042542 response to hydrogen peroxide
GO:0043266 regulation of potassium ion transport
GO:0045121 membrane raft
GO:0046691 intracellular canaliculus
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0051260 protein homooligomerization
GO:0051393 alpha-actinin binding
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0055075 potassium ion homeostasis
GO:0055093 response to hyperoxia
GO:0060081 membrane hyperpolarization
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0071805 potassium ion transmembrane transport
GO:0086014 atrial cardiac muscle cell action potential
GO:0086050 membrane repolarization during bundle of His cell action potential
GO:0086052 membrane repolarization during SA node cell action potential
GO:0086087 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0086090 voltage-gated potassium channel activity involved in SA node cell action potential repolarization
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097110 scaffold protein binding
GO:0097623 potassium ion export across plasma membrane
GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000288 positive regulation of myoblast proliferation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR003131 Potassium channel tetramerisation-type BTB domainDomainDomain
IPR003968 Potassium channel, voltage dependent, KvFamilyFamily
IPR003972 Potassium channel, voltage dependent, Kv1FamilyFamily
IPR004052 Potassium channel, voltage dependent, Kv1.5FamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR028325 Voltage-gated potassium channelFamilyFamily

Diseases

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Disease IDSourceNameDescription
612240 OMIMAtrial fibrillation, familial, 7 (ATFB7)A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB06217 VernakalantDrugbanksmall molecule
DB06637 DalfampridineDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
KCNA5_HUMANACTN2_HUMANbhf-ucl, BioGRID, HPRD, MINT10812072 11389904 12860415 details
KCNA5_HUMANSCRIB_HUMANMINT24550280 details
KCNA5_HUMANDLG1_HUMANBioGRID, HPRD, MINT12970345 16466689 24550280 details
KCNA5_HUMANTM107_HUMANBioGRID, IntAct32296183 details
KCNA5_HUMANKCNA3_HUMANBioGRID, IntAct18218624 28514442 details
KCNA5_HUMANUBC9_HUMANBioGRID, DIP17261810 details
KCNA5_HUMANDLG4_HUMANBioGRID, HPRD12435606 12860415 16466689 details
KCNA5_HUMANACK1_HUMANBioGRID14506255 details
KCNA5_HUMANERBIN_HUMANBioGRID15123239 details
KCNA5_HUMANSNTA1_HUMANBioGRID15123239 details
KCNA5_HUMANHS90B_HUMANIntAct22939624 details
KCNA5_HUMANKCAB2_HUMANBioGRID, IntAct23390957 28514442 details
KCNA5_HUMANSUMO1_HUMANDIP17261810 details
KCNA5_HUMANSUMO3_HUMANDIP17261810 details
KCNA5_HUMANSUMO2_HUMANDIP17261810 details
KCNA5_HUMANKCNA2_HUMANBioGRID, HPRD11149959 12815189 details
KCNA5_HUMANFHL1_HUMANBioGRID18281375 22053194 details
KCNA5_HUMANRAB5A_HUMANBioGRID18755741 details
KCNA5_HUMANRAB4A_HUMANBioGRID18755741 details
KCNA5_HUMANSRC_HUMANBioGRID, HPRD11149959 8953041 details
KCNA5_HUMANTFR1_HUMANBioGRID18218624 details
KCNA5_HUMANCAV1_HUMANBioGRID18218624 26931497 27075359 details
KCNA5_HUMANKCNA5_HUMANBioGRID18218624 details
KCNA5_HUMANKCNA4_HUMANBioGRID11149959 details
KCNA5_HUMANFYN_HUMANBioGRID11149959 details
KCNA5_HUMANKCAB1_HUMANBioGRID22547057 details
KCNA5_HUMANRACK1_HUMANBioGRID22547057 details
KCNA5_HUMANKPCB_HUMANBioGRID22547057 details
KCNA5_HUMANKPCT_HUMANBioGRID22547057 details
KCNA5_HUMANDC1I1_HUMANBioGRID16051887 details
KCNA5_HUMANDCTN2_HUMANBioGRID16051887 details
KCNA5_HUMANHS90A_HUMANBioGRID22939624 details
KCNA5_HUMANSIR1_HUMANBioGRID23390957 details
KCNA5_HUMANCHIP_HUMANBioGRID26232501 details
KCNA5_HUMANHSP7C_HUMANBioGRID26232501 details
KCNA5_HUMANPTPRE_HUMANHPRD10921884 15588985 details