Entity Details

Primary name CMA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23946
EntryNameCMA1_HUMAN
FullNameChymase
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesCMA1

GO terms

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GOName
GO:0002003 angiotensin maturation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0008236 serine-type peptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030141 secretory granule
GO:0030901 midbrain development
GO:0034769 basement membrane disassembly
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042277 peptide binding
GO:0045766 positive regulation of angiogenesis
GO:0050727 regulation of inflammatory response
GO:0062023 collagen-containing extracellular matrix
GO:0071333 cellular response to glucose stimulus
GO:0140447 cytokine precursor processing

Subcellular Location

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Subcellular Location
Cytoplasmic granule
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03297 Benzylsulfonic acidDrugbanksmall molecule
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB04016 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic AcidDrugbanksmall molecule
DB07680 [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACIDDrugbanksmall molecule