Entity Details

Primary name DNJB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25686
EntryNameDNJB2_HUMAN
FullNameDnaJ homolog subfamily B member 2
TaxID9606
Evidenceevidence at protein level
Length324
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesDNAJB2

GO terms

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GOName
GO:0001671 ATPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006986 response to unfolded protein
GO:0008285 negative regulation of cell population proliferation
GO:0016234 inclusion body
GO:0030308 negative regulation of cell growth
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030544 Hsp70 protein binding
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031965 nuclear membrane
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032781 positive regulation of ATPase activity
GO:0032880 regulation of protein localization
GO:0042026 protein refolding
GO:0042406 extrinsic component of endoplasmic reticulum membrane
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0061077 chaperone-mediated protein folding
GO:0070050 neuron cellular homeostasis
GO:0070628 proteasome binding
GO:0090084 negative regulation of inclusion body assembly
GO:0090086 negative regulation of protein deubiquitination
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:0140036 ubiquitin-dependent protein binding
GO:1903644 regulation of chaperone-mediated protein folding

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001623 DnaJ domainDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR018253 DnaJ domain, conserved siteSiteConserved site
IPR036869 Chaperone J-domain superfamilyFamilyHomologous superfamily
IPR043183 DnaJ homolog subfamily B member 2FamilyFamily

Diseases

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