Entity Details

Primary name CATS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25774
EntryNameCATS_HUMAN
FullNameCathepsin S
TaxID9606
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesCTSS

GO terms

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GOName
GO:0001968 fibronectin binding
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005770 late endosome
GO:0006508 proteolysis
GO:0006955 immune response
GO:0010447 response to acidic pH
GO:0016485 protein processing
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 extracellular matrix disassembly
GO:0030574 collagen catabolic process
GO:0034769 basement membrane disassembly
GO:0036021 endolysosome lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043236 laminin binding
GO:0043312 neutrophil degranulation
GO:0043394 proteoglycan binding
GO:0045335 phagocytic vesicle
GO:0048002 antigen processing and presentation of peptide antigen
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0062023 collagen-containing extracellular matrix
GO:0097067 cellular response to thyroid hormone stimulus
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen
GO:2001259 positive regulation of cation channel activity

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03767 Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]AmideDrugbanksmall molecule
DB03837 Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-AmideDrugbanksmall molecule
DB03984 Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-AmideDrugbanksmall molecule
DB07520 N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDrugbanksmall molecule
DB07587 N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDrugbanksmall molecule
DB07589 N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDEDrugbanksmall molecule
DB07839 N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDEDrugbanksmall molecule
DB07878 N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDEDrugbanksmall molecule
DB08195 (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATEDrugbanksmall molecule
DB08611 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOLDrugbanksmall molecule
DB08752 N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDrugbanksmall molecule
DB08755 N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule