Entity Details

Primary name 3BHS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26439
EntryName3BHS2_HUMAN
FullName3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-04-07

Ontological Relatives

GenesHSD3B2

GO terms

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GOName
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 steroid delta-isomerase activity
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0008207 C21-steroid hormone metabolic process
GO:0016021 integral component of membrane
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0021766 hippocampus development
GO:0030868 smooth endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045171 intercellular bridge
GO:0051412 response to corticosterone
GO:0102294 cholesterol dehydrogenase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR002225 3-beta hydroxysteroid dehydrogenase/isomeraseDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB01108 TrilostaneDrugbanksmall molecule
DB01285 CorticotropinDrugbankbiotech
DB09070 TiboloneDrugbanksmall molecule

Interactions

3 interactions