Entity Details

Primary name PON1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27169
EntryNamePON1_HUMAN
FullNameSerum paraoxonase/arylesterase 1
TaxID9606
Evidenceevidence at protein level
Length355
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPON1

GO terms

Show/Hide Table
GOName
GO:0004063 aryldialkylphosphatase activity
GO:0004064 arylesterase activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008203 cholesterol metabolic process
GO:0009636 response to toxic substance
GO:0010875 positive regulation of cholesterol efflux
GO:0019372 lipoxygenase pathway
GO:0019439 aromatic compound catabolic process
GO:0031667 response to nutrient levels
GO:0032411 positive regulation of transporter activity
GO:0034364 high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0046395 carboxylic acid catabolic process
GO:0046434 organophosphate catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0051099 positive regulation of binding
GO:0070062 extracellular exosome
GO:0070542 response to fatty acid
GO:0072562 blood microparticle
GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity
GO:1902617 response to fluoride

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR002640 ArylesteraseFamilyFamily
IPR008363 Paraoxonase1FamilyFamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01327 CefazolinDrugbanksmall molecule
DB01395 DrospirenoneDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule
DB14596 Loteprednol etabonateDrugbanksmall molecule
DB14598 Edetate calcium disodium anhydrousSwissprotsmall molecule
DB14600 Edetate disodium anhydrousSwissprotsmall molecule

Interactions

3 interactions