Entity Details

Primary name HLAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30511
EntryNameHLAF_HUMAN
FullNameHLA class I histocompatibility antigen, alpha chain F
TaxID9606
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-F

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002725 negative regulation of T cell cytokine production
GO:0002728 negative regulation of natural killer cell cytokine production
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032398 MHC class Ib protein complex
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043322 negative regulation of natural killer cell degranulation
GO:0043323 positive regulation of natural killer cell degranulation
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:0050776 regulation of immune response
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0071889 14-3-3 protein binding
GO:1901215 negative regulation of neuron death

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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