Entity Details

Primary name ACHA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32297
EntryNameACHA3_HUMAN
FullNameNeuronal acetylcholine receptor subunit alpha-3
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCHRNA3

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0006811 ion transport
GO:0006940 regulation of smooth muscle contraction
GO:0007165 signal transduction
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007268 chemical synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007399 nervous system development
GO:0007626 locomotory behavior
GO:0014056 regulation of acetylcholine secretion, neurotransmission
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
GO:0016021 integral component of membrane
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0034220 ion transmembrane transport
GO:0035095 behavioral response to nicotine
GO:0042166 acetylcholine binding
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044853 plasma membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048814 regulation of dendrite morphogenesis
GO:0050877 nervous system process
GO:0060079 excitatory postsynaptic potential
GO:0060084 synaptic transmission involved in micturition
GO:0095500 acetylcholine receptor signaling pathway
GO:1905144 response to acetylcholine

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00184 NicotineDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00848 LevamisoleDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB01090 PentoliniumDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01227 LevacetylmethadolDrugbanksmall molecule
DB01273 VareniclineDrugbanksmall molecule
DB05710 GantacuriumDrugbanksmall molecule
DB07720 EpibatidineDrugbanksmall molecule
DB09028 CytisineDrugbanksmall molecule

Interactions

4 interactions