Entity Details

Primary name GCYA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33402
EntryNameGCYA2_HUMAN
FullNameGuanylate cyclase soluble subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length732
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesGUCY1A2

GO terms

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GOName
GO:0004383 guanylate cyclase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0007165 signal transduction
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0020037 heme binding
GO:0035556 intracellular signal transduction
GO:0044877 protein-containing complex binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR011644 Heme NO-bindingDomainDomain
IPR011645 Haem NO binding associatedDomainDomain
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR024096 NO signalling/Golgi transport ligand-binding domain superfamilyFamilyHomologous superfamily
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR038158 H-NOX domain superfamilyFamilyHomologous superfamily
IPR042463 Haem NO binding associated domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00435 Nitric OxideDrugbanksmall molecule
DB01020 Isosorbide mononitrateDrugbanksmall molecule
DB06154 Pentaerythritol tetranitrateDrugbanksmall molecule
DB08931 RiociguatDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09282 MolsidomineDrugbanksmall molecule
DB13170 PlecanatideDrugbanksmall molecule
DB13749 Magnesium gluconateSwissprotsmall molecule