Entity Details

Primary name ABL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42684
EntryNameABL2_HUMAN
FullNameTyrosine-protein kinase ABL2
TaxID9606
Evidenceevidence at protein level
Length1182
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesABL2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001784 phosphotyrosine residue binding
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010506 regulation of autophagy
GO:0010863 positive regulation of phospholipase C activity
GO:0010976 positive regulation of neuron projection development
GO:0015629 actin cytoskeleton
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030100 regulation of endocytosis
GO:0030145 manganese ion binding
GO:0030155 regulation of cell adhesion
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035640 exploration behavior
GO:0051015 actin filament binding
GO:0051353 positive regulation of oxidoreductase activity
GO:0071300 cellular response to retinoic acid
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015015 F-actin bindingDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035837 Tyrosine-protein kinase ABL, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB07664 K-00546Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
ABL2_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
ABL2_HUMANERBB4_HUMANBioGRID, MINT16273093 22973453 details
ABL2_HUMANERBB2_HUMANBioGRID, MINT16273093 19275932 22973453 details
ABL2_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 24658140 25402006 31980649 details
ABL2_HUMANCRK_HUMANBioGRID, HPRD, IntAct11956190 12198159 15886098 17474147 19380743 25814554 8194526 8875975 9480911 9642287 details
ABL2_HUMANPLCG1_HUMANIntAct17474147 details
ABL2_HUMANSRC_HUMANIntAct17474147 details
ABL2_HUMANFYN_HUMANIntAct17474147 details
ABL2_HUMANGRB2_HUMANBioGRID, IntAct17474147 8194526 details
ABL2_HUMANNCK1_HUMANBioGRID, IntAct17474147 25241761 details
ABL2_HUMANP85A_HUMANIntAct17474147 details
ABL2_HUMANMED28_HUMANBioGRID, MINT16964398 details
ABL2_HUMANABI1_HUMANMINT20598684 details
ABL2_HUMANM3K10_HUMANBioGRID, IntAct20936779 details
ABL2_HUMANHCK_HUMANBioGRID, HPRD, IntAct12748290 21988832 details
ABL2_HUMANTPD53_HUMANBioGRID, IntAct21988832 details
ABL2_HUMANFBX38_HUMANBioGRID, IntAct21988832 details
ABL2_HUMANNMES1_HUMANBioGRID, IntAct21988832 details
ABL2_HUMANMS18B_HUMANBioGRID, IntAct21988832 details
ABL2_HUMANANDR_HUMANBioGRID, IntAct24728074 details
ABL2_HUMANKIT_HUMANBioGRID, IntAct24728074 details
ABL2_HUMANMET_HUMANBioGRID, IntAct24728074 details
ABL2_HUMANP55G_HUMANBioGRID, IntAct25814554 details
ABL2_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
ABL2_HUMANLRRK2_HUMANIntAct24947832 details
ABL2_HUMANCIP4_HUMANBioGRID, DIP, IntAct18330356 32296183 details
ABL2_HUMANABI2_HUMANBioGRID, IntAct28514442 32296183 details
ABL2_HUMANCAV1_HUMANDIP20808760 details
ABL2_HUMANFLT3_HUMANMINT28086240 details
ABL2_HUMANABL1_HUMANBioGRID, HPRD12569093 15735735 details
ABL2_HUMANCATA_HUMANBioGRID, HPRD12777400 details
ABL2_HUMANSRBS2_HUMANBioGRID, HPRD9211900 details
ABL2_HUMANEPHB2_HUMANBioGRID, HPRD11494128 details
ABL2_HUMANNEDD4_HUMANBioGRID19953087 details
ABL2_HUMANNED4L_HUMANBioGRID19953087 details
ABL2_HUMANPSA7_HUMANBioGRID16678104 details
ABL2_HUMANDOK1_HUMANBioGRID22974441 details
ABL2_HUMANGPX1_HUMANBioGRID, HPRD12893824 details
ABL2_HUMANABL2_HUMANBioGRID15735735 15886098 details
ABL2_HUMANMDM2_HUMANBioGRID25624478 details
ABL2_HUMANPGFRB_HUMANBioGRID19275932 details
ABL2_HUMANZMAT1_HUMANBioGRID32296183 details
ABL2_HUMANTMG4_HUMANBioGRID23873930 details
ABL2_HUMANRIN1_HUMANBioGRID, HPRD, IntAct15886098 28514442 details
ABL2_HUMANSRC8_HUMANmbinfo21257711 details
ABL2_HUMANSF01_HUMANIntAct26420826 details
ABL2_HUMANEPHA4_HUMANIntAct31413325 details
ABL2_HUMANJAK1_HUMANBioGRID9774693 details
ABL2_HUMANUFO_HUMANBioGRID18346204 details
ABL2_HUMANBCR_HUMANHPRD1383690 details
ABL2_HUMANSIVA_HUMANHPRD11278261 details