Entity Details

Primary name FRK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42685
EntryNameFRK_HUMAN
FullNameTyrosine-protein kinase FRK
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesFRK

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005622 intracellular anatomical structure
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008285 negative regulation of cell population proliferation
GO:0030154 cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035805 Tyrosine-protein kinase Frk, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule