Entity Details

Primary name WASP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42768
EntryNameWASP_HUMAN
FullNameWiskott-Aldrich syndrome protein
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesWAS

GO terms

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GOName
GO:0002625 regulation of T cell antigen processing and presentation
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006952 defense response
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008544 epidermis development
GO:0010591 regulation of lamellipodium assembly
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0016197 endosomal transport
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030048 actin filament-based movement
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0032488 Cdc42 protein signal transduction
GO:0035861 site of double-strand break
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045335 phagocytic vesicle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050852 T cell receptor signaling pathway
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071346 cellular response to interferon-gamma
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000146 negative regulation of cell motility
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000697 WH1/EVH1 domainDomainDomain
IPR003124 WH2 domainDomainDomain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminalFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR027641 Wiskott-Aldrich syndrome proteinFamilyFamily
IPR033927 WASP family, EVH1 domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01731 (S)-wiskostatinDrugbanksmall molecule

Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
WASP_HUMANCDC42_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo, MINT10068673 10360578 10360579 10684602 10713100 10724160 10802735 12235133 12769846 15075243 15361624 20936779 22252508 25502805 28539360 31515488 8625410 8643625 9422512 9660763 9742969 details
WASP_HUMANFGR_HUMANBioGRID, HPRD, MINT10358777 7565724 8805332 8824280 details
WASP_HUMANNCK1_HUMANBioGRID, HPRD, MINT10747096 11340081 12135674 24287595 7565724 details
WASP_HUMANFYN_HUMANBioGRID, HPRD, MINT10224664 10532312 12431372 14707117 7565724 8805332 details
WASP_HUMANARC1B_HUMANHPRD, mbinfo, MINT10861055 11943145 details
WASP_HUMANHCK_HUMANBioGRID, HPRD, mbinfo, MINT10068673 12029088 12235133 12769846 19234535 9742969 details
WASP_HUMANPPIP1_HUMANBioGRID, HPRD, MINT14707117 19041431 9488710 details
WASP_HUMANPTN12_HUMANHPRD, IntAct, MINT11711533 14707117 15588985 19167335 details
WASP_HUMANWASP_HUMANDIP, HPRD, IntAct10724160 12769847 18650809 details
WASP_HUMANCSK21_HUMANBioGRID, HPRD, IntAct12769847 details
WASP_HUMANARPC3_HUMANBioGRID, IntAct12769847 23148219 9889097 details
WASP_HUMANWIPF1_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo10202051 12591280 16055720 16488394 17213309 19805221 19817875 21988832 25416956 32296183 9405671 9694849 details
WASP_HUMANGAS7_HUMANBioGRID, MINT16055720 26506240 details
WASP_HUMANWBP4_HUMANBioGRID, MINT16055720 details
WASP_HUMANPTPRC_HUMANIntAct19167335 details
WASP_HUMANPTPRG_HUMANIntAct19167335 details
WASP_HUMANPTPRZ_HUMANIntAct19167335 details
WASP_HUMANPTPRB_HUMANIntAct19167335 details
WASP_HUMANPTPRJ_HUMANIntAct19167335 details
WASP_HUMANPTPRO_HUMANIntAct19167335 details
WASP_HUMANPTN22_HUMANIntAct19167335 details
WASP_HUMANLCK_HUMANBioGRID, MINT16107303 16293614 details
WASP_HUMANSNX9_HUMANBioGRID, DIP, MINT17242350 19487689 details
WASP_HUMANDVL2_HUMANBioGRID, MINT21516116 details
WASP_HUMANABI3_HUMANBioGRID, IntAct, MINT21516116 25416956 details
WASP_HUMANFCSD2_HUMANBioGRID, IntAct21988832 details
WASP_HUMANRGS14_HUMANBioGRID, IntAct21988832 details
WASP_HUMANWIPF2_HUMANBioGRID, HPRD, IntAct12213210 16055720 21988832 details
WASP_HUMANRHOJ_HUMANBioGRID, HPRD, mbinfo10967094 14521508 details
WASP_HUMANROBO4_HUMANmbinfo18948384 details
WASP_HUMANBTK_HUMANbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
WASP_HUMANPLCG1_HUMANbhf-ucl, BioGRID, HPRD8805332 8824280 8892607 details
WASP_HUMANITK_HUMANbhf-ucl, BioGRID, HPRD8810341 8892607 details
WASP_HUMANTEC_HUMANbhf-ucl, BioGRID, HPRD8892607 details
WASP_HUMANGRB2_HUMANbhf-ucl, BioGRID, HPRD10224664 8805332 8892607 9307968 details
WASP_HUMANNCK2_HUMANBioGRID, IntAct24287595 25416956 details
WASP_HUMANSRBS2_HUMANBioGRID, IntAct25416956 details
WASP_HUMANAPBP2_HUMANBioGRID, IntAct25416956 details
WASP_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
WASP_HUMANCIP4_HUMANBioGRID, HPRD10713100 21516116 details
WASP_HUMANP85A_HUMANBioGRID, HPRD10358777 17242350 8805332 details
WASP_HUMANSRC_HUMANBioGRID, HPRD8805332 8824280 details
WASP_HUMANCRKL_HUMANBioGRID, HPRD11313252 details
WASP_HUMANVASP_HUMANBioGRID, HPRD11598004 16055720 details
WASP_HUMANRAC1_HUMANBioGRID, HPRD8643625 details
WASP_HUMANITSN2_HUMANBioGRID, HPRD11748279 22558309 details
WASP_HUMANACK1_HUMANBioGRID16257963 details
WASP_HUMANARPC2_HUMANBioGRID11943145 details
WASP_HUMANBI2L1_HUMANBioGRID22921828 details
WASP_HUMANTCRG1_HUMANBioGRID16055720 details
WASP_HUMANPR40A_HUMANBioGRID16055720 details
WASP_HUMANAPBB1_HUMANBioGRID16055720 details
WASP_HUMANRBP2_HUMANBioGRID26261240 details
WASP_HUMANC5AR1_HUMANBioGRID, HPRD12600272 details
WASP_HUMANCBP_HUMANBioGRID32238831 details
WASP_HUMANRHG01_HUMANHPRD8805223 details
WASP_HUMANCIB1_HUMANHPRD16582881 details
WASP_HUMANSNX33_HUMANMINT19487689 details
WASP_HUMANSRC8_HUMANmbinfo15169891 details
WASP_HUMANRAC2_HUMANmbinfo14521508 details
WASP_HUMANRAC3_HUMANmbinfo14521508 details
WASP_HUMANRHOQ_HUMANmbinfo14521508 details
WASP_HUMANHCLS1_HUMANHPRD, mbinfo15166239 21398607 details
WASP_HUMANEGFR_HUMANBioGRID9307968 details
WASP_HUMANFYB1_HUMANBioGRID, HPRD10747096 details
WASP_HUMANLCP2_HUMANBioGRID, HPRD10747096 details
WASP_HUMANPACN1_HUMANBioGRID19041431 details
WASP_HUMANPACN2_HUMANBioGRID19041431 details
WASP_HUMANPACN3_HUMANBioGRID19041431 details
WASP_HUMANFNBP1_HUMANBioGRID16418535 19041431 details
WASP_HUMANSRGP2_HUMANBioGRID19041431 details
WASP_HUMANRBBP5_HUMANBioGRID20574068 details
WASP_HUMANJMJD6_HUMANBioGRID20574068 details
WASP_HUMANKDM4A_HUMANBioGRID20574068 details
WASP_HUMANKDM6B_HUMANBioGRID20574068 details
WASP_HUMANITSN1_HUMANBioGRID15824104 18539136 details
WASP_HUMANCBL_HUMANBioGRID23684068 details
WASP_HUMANCBLB_HUMANBioGRID23684068 details
WASP_HUMANCSK22_HUMANHPRD12769847 details
WASP_HUMANACTC_HUMANHPRD12029088 details
WASP_HUMANDLG1_HUMANHPRD15699074 details
WASP_HUMANSPN90_HUMANHPRD14559906 details
WASP_HUMANARHG7_HUMANHPRD14559906 details
WASP_HUMANEVL_HUMANHPRD16055720 details
WASP_HUMANENAH_HUMANHPRD16055720 details