Entity Details

Primary name PE2R3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43115
EntryNamePE2R3_HUMAN
FullNameProstaglandin E2 receptor EP3 subtype
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTGER3

GO terms

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GOName
GO:0004957 prostaglandin E receptor activity
GO:0005635 nuclear envelope
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008219 cell death
GO:0014827 intestine smooth muscle contraction
GO:0016021 integral component of membrane
GO:0031622 positive regulation of fever generation
GO:0060455 negative regulation of gastric acid secretion

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000265 Prostanoid EP3 receptorFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001244 Prostaglandin DP receptorFamilyFamily
IPR001481 Prostanoid EP3 receptor, type 2FamilyFamily
IPR008365 Prostanoid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00905 BimatoprostDrugbanksmall molecule
DB00917 DinoprostoneDrugbanksmall molecule
DB00929 MisoprostolDrugbanksmall molecule
DB08964 GemeprostDrugbanksmall molecule
DB09211 LimaprostDrugbanksmall molecule
DB11113 Castor oilDrugbankbiotech