Entity Details

Primary name GSH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48506
EntryNameGSH1_HUMAN
FullNameGlutamate--cysteine ligase catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length637
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGCLC

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004357 glutamate-cysteine ligase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0016595 glutamate binding
GO:0017109 glutamate-cysteine ligase complex
GO:0043066 negative regulation of apoptotic process
GO:0043531 ADP binding
GO:0045454 cell redox homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097746 blood vessel diameter maintenance

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004308 Glutamate-cysteine ligase catalytic subunitFamilyFamily
IPR014746 Glutamine synthetase/guanido kinase, catalytic domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB00163 Vitamin EDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GSH1_HUMANCCL22_HUMANBioGRID, IntAct21988832 details
GSH1_HUMANGSH0_HUMANBioGRID, IntAct26344197 28514442 9675072 9841880 details