Entity Details

Primary name PK3CG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48736
EntryNamePK3CG_HUMAN
FullNamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
TaxID9606
Evidenceevidence at protein level
Length1102
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3CG

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001819 positive regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002675 positive regulation of acute inflammatory response
GO:0002679 respiratory burst involved in defense response
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010595 positive regulation of endothelial cell migration
GO:0010818 T cell chemotaxis
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0032252 secretory granule localization
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035747 natural killer cell chemotaxis
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0055118 negative regulation of cardiac muscle contraction
GO:0070527 platelet aggregation
GO:0071320 cellular response to cAMP
GO:0072672 neutrophil extravasation
GO:0097284 hepatocyte apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903169 regulation of calcium ion transmembrane transport
GO:2000270 negative regulation of fibroblast apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB02375 MyricetinDrugbanksmall molecule
DB02656 LY-294002Drugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04769 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONEDrugbanksmall molecule
DB05241 XL765Drugbanksmall molecule
DB05552 TG100-115Drugbanksmall molecule
DB06831 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONEDrugbanksmall molecule
DB06836 N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamideDrugbanksmall molecule
DB07073 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-oneDrugbanksmall molecule
DB07335 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLDrugbanksmall molecule
DB07503 (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONEDrugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB08300 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineDrugbanksmall molecule
DB11952 DuvelisibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
PK3CG_HUMANRASH_HUMANBioGRID, HPRD, MINT11136978 details
PK3CG_HUMANPK3CG_HUMANDIP, IntAct20562859 23824069 details
PK3CG_HUMANZN282_HUMANBioGRID, MINT21900206 details
PK3CG_HUMANPI3R5_HUMANBioGRID, HPRD, IntAct10488142 12507995 16476736 25241761 details
PK3CG_HUMANKPCB_HUMANDIP23824069 details
PK3CG_HUMANA4_HUMANIntAct32814053 details
PK3CG_HUMANPK3CD_HUMANBioGRID9113989 details
PK3CG_HUMANLYN_HUMANBioGRID, HPRD10318860 7721825 details
PK3CG_HUMANRASN_HUMANBioGRID11136978 details
PK3CG_HUMANRASK_HUMANBioGRID, HPRD10542052 details
PK3CG_HUMANSET_HUMANBioGRID21419339 details
PK3CG_HUMANPI3R6_HUMANBioGRID16476736 details
PK3CG_HUMANGAB1_HUMANBioGRID, HPRD10871282 11453982 details
PK3CG_HUMANPTN11_HUMANBioGRID, HPRD10386953 20723025 details
PK3CG_HUMANCD37_HUMANIntAct22624718 details
PK3CG_HUMANPDE3B_HUMANUniProt21393242 details
PK3CG_HUMANKIT_HUMANBioGRID, HPRD, IntAct25241761 7520444 details
PK3CG_HUMANBCR_HUMANBioGRID, IntAct25241761 7606002 details
PK3CG_HUMANRASE_HUMANBioGRID12774123 details
PK3CG_HUMANEPHA8_HUMANBioGRID, HPRD11416136 details
PK3CG_HUMANKSYK_HUMANBioGRID7721825 details
PK3CG_HUMANPECA1_HUMANBioGRID20723025 details
PK3CG_HUMANLAT_HUMANBioGRID20723025 details
PK3CG_HUMANRARA_HUMANBioGRID17595318 details
PK3CG_HUMANP85A_HUMANBioGRID17595318 details
PK3CG_HUMANNOTC1_HUMANHPRD14583609 details
PK3CG_HUMANARBK1_HUMANHPRD12163475 details
PK3CG_HUMANIL6RB_HUMANHPRD10579793 details
PK3CG_HUMANNSMA_HUMANHPRD11238738 details
PK3CG_HUMANS14L2_HUMANHPRD12757856 details
PK3CG_HUMANCD28_HUMANHPRD9915850 details
PK3CG_HUMANGRB2_HUMANHPRD10386953 details
PK3CG_HUMANTPM2_HUMANHPRD16094730 details
PK3CG_HUMANGELS_HUMANHPRD11577104 details