Entity Details

Primary name CCN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48745
EntryNameCCN3_HUMAN
FullNameCCN family member 3
TaxID9606
Evidenceevidence at protein level
Length357
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCCN3

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002062 chondrocyte differentiation
GO:0005112 Notch binding
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005921 gap junction
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0010468 regulation of gene expression
GO:0010761 fibroblast migration
GO:0010832 negative regulation of myotube differentiation
GO:0014909 smooth muscle cell migration
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0030425 dendrite
GO:0031012 extracellular matrix
GO:0033627 cell adhesion mediated by integrin
GO:0035767 endothelial cell chemotaxis
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0044342 type B pancreatic cell proliferation
GO:0045747 positive regulation of Notch signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048659 smooth muscle cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0060326 cell chemotaxis
GO:0060392 negative regulation of SMAD protein signal transduction
GO:0060548 negative regulation of cell death
GO:0061484 hematopoietic stem cell homeostasis
GO:0062023 collagen-containing extracellular matrix
GO:0071603 endothelial cell-cell adhesion
GO:0090027 negative regulation of monocyte chemotaxis
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1902731 negative regulation of chondrocyte proliferation
GO:1904057 negative regulation of sensory perception of pain
GO:1990523 bone regeneration

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001007 VWFC domainDomainDomain
IPR006207 Cystine knot, C-terminalDomainDomain
IPR006208 Glycoprotein hormone subunit betaDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR012395 IGFBP-related, CNNFamilyFamily
IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved siteSiteConserved site
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR043973 CCN, TSP1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00071 Insulin porkDrugbankbiotech

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
CCN3_HUMANPUR8_HUMANBioGRID, IntAct21988832 details
CCN3_HUMANMACOI_HUMANIntAct32296183 details
CCN3_HUMANFRS3_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANLCE3D_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANKRA56_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANHXA1_HUMANBioGRID, IntAct, MINT21653829 32296183 details
CCN3_HUMANCK087_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANPO4F2_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANZN330_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANTNIP3_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANCO8A1_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANLCE1A_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANAPOL6_HUMANBioGRID, IntAct32296183 details
CCN3_HUMANRPAB5_HUMANBioGRID, HPRD10474687 details
CCN3_HUMANITAV_HUMANBioGRID12902636 details
CCN3_HUMANFINC_HUMANBioGRID, HPRD12902636 details
CCN3_HUMANIGF1_HUMANBioGRID, HPRD10084601 details
CCN3_HUMANIGF2_HUMANBioGRID, HPRD10084601 details
CCN3_HUMANINS_HUMANBioGRID, HPRD10084601 details
CCN3_HUMANNOTC1_HUMANBioGRID, HPRD12050162 details
CCN3_HUMANFBLN1_HUMANBioGRID, HPRD9927660 details
CCN3_HUMANCDN1A_HUMANBioGRID8756624 details
CCN3_HUMANS10A4_HUMANBioGRID, HPRD12147716 14606958 details
CCN3_HUMANNID2_HUMANBioGRID32296183 details
CCN3_HUMANRECK_HUMANBioGRID32296183 details
CCN3_HUMANANR11_HUMANBioGRID32296183 details
CCN3_HUMANCCN2_HUMANHPRD9927660 details
CCN3_HUMANFXR1_HUMANMINT21653829 details
CCN3_HUMANFXR2_HUMANMINT21653829 details
CCN3_HUMANCDK2_HUMANBioGRID15647383 details
CCN3_HUMANDLL1_HUMANHPRD12050162 details
CCN3_HUMANCXA1_HUMANHPRD15181016 details