Entity Details

Primary name MAPK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49137
EntryNameMAPK2_HUMAN
FullNameMAP kinase-activated protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesMAPKAPK2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0032496 response to lipopolysaccharide
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034097 response to cytokine
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038066 p38MAPK cascade
GO:0043488 regulation of mRNA stability
GO:0044351 macropinocytosis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048839 inner ear development
GO:0051019 mitogen-activated protein kinase binding
GO:0070062 extracellular exosome
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR027442 MAP kinase activated protein kinase, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB07234 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dioneDrugbanksmall molecule
DB07406 (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDEDrugbanksmall molecule
DB07430 (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-oneDrugbanksmall molecule
DB07431 (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-oneDrugbanksmall molecule
DB07728 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule
DB08358 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDrugbanksmall molecule

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
MAPK2_HUMANLIMK1_HUMANBioGRID, MINT16456544 details
MAPK2_HUMANHSF1_HUMANBioGRID, HPRD, IntAct16278218 details
MAPK2_HUMANMPIP1_HUMANIntAct17292828 details
MAPK2_HUMANMK14_HUMANBioGRID, HPRD, IntAct10581204 10922375 11042204 17255097 17395714 21675959 21988832 23455922 23602568 25241761 25852190 26186194 26496610 28514442 31980649 7592979 8846784 9768359 details
MAPK2_HUMANHSPB1_HUMANBioGRID, HPRD, IntAct, Molecular Connections10383393 10978313 11042204 11839738 11844797 12740362 12829704 1332886 14499342 14688255 15850461 17170118 18326031 21131586 21575178 25241761 26616734 7799959 8774846 8995385 details
MAPK2_HUMANAATF_HUMANMINT22909821 details
MAPK2_HUMANAKT1_HUMANBioGRID, HPRD, IntAct11042204 17510053 25241761 details
MAPK2_HUMANLOX5_HUMANBioGRID, HPRD, MINT10779545 11844797 24860872 details
MAPK2_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
MAPK2_HUMANMAPK2_HUMANBioGRID, HPRD, UniProt18695677 20057052 21675959 31837246 8846784 8995385 details
MAPK2_HUMANSHC1_HUMANBioGRID, HPRD15094067 details
MAPK2_HUMANPHC2_HUMANBioGRID, HPRD15094067 21675959 details
MAPK2_HUMANMK01_HUMANBioGRID12861023 15094067 21675959 8995385 details
MAPK2_HUMANETV1_HUMANBioGRID, HPRD11551945 details
MAPK2_HUMANCSK2B_HUMANBioGRID21675959 details
MAPK2_HUMANMK03_HUMANBioGRID14499342 21675959 details
MAPK2_HUMANMAPK5_HUMANBioGRID21675959 details
MAPK2_HUMANTISB_HUMANBioGRID17030608 18326031 details
MAPK2_HUMANROA0_HUMANBioGRID, HPRD12456657 details
MAPK2_HUMANMPIP2_HUMANBioGRID15629715 details
MAPK2_HUMANPARN_HUMANBioGRID20932473 details
MAPK2_HUMANPABP1_HUMANBioGRID12565831 details
MAPK2_HUMANUB2J1_HUMANBioGRID24020373 details
MAPK2_HUMANDESM_HUMANBioGRID15094067 details
MAPK2_HUMANMP2K6_HUMANBioGRID17255097 details
MAPK2_HUMANTFE2_HUMANBioGRID, HPRD10781029 details
MAPK2_HUMANPIAS2_HUMANBioGRID23202365 details
MAPK2_HUMANDDX5_HUMANBioGRID23482664 details
MAPK2_HUMANLSP1_HUMANBioGRID, HPRD8995217 details
MAPK2_HUMANTIF1B_HUMANBioGRID23740979 details
MAPK2_HUMAN1433Z_HUMANBioGRID, HPRD12861023 details
MAPK2_HUMANTTP_HUMANBioGRID, HPRD14688255 18326031 details
MAPK2_HUMANATF1_HUMANBioGRID11335727 details
MAPK2_HUMANAGO2_HUMANBioGRID18476811 details
MAPK2_HUMANPLK1_HUMANBioGRID18695677 details
MAPK2_HUMANCPZIP_HUMANBioGRID15850461 details
MAPK2_HUMANARPC5_HUMANBioGRID, HPRD12829704 details
MAPK2_HUMANWASF1_HUMANBioGRID12829704 details
MAPK2_HUMANMDM2_HUMANBioGRID15688025 details
MAPK2_HUMANCP131_HUMANBioGRID26616734 details
MAPK2_HUMANBECN1_HUMANBioGRID25693418 details
MAPK2_HUMANTRI29_HUMANBioGRID24469230 details
MAPK2_HUMANB2CL1_HUMANBioGRID22617334 details
MAPK2_HUMANLYAR_HUMANIntAct17353931 details
MAPK2_HUMANSPF30_HUMANIntAct17353931 details
MAPK2_HUMANPINX1_HUMANIntAct17353931 details
MAPK2_HUMANMK11_HUMANBioGRID, IntAct11551945 23602568 details
MAPK2_HUMANP52K_HUMANBioGRID20484669 details
MAPK2_HUMANTSC2_HUMANHPRD12582162 details
MAPK2_HUMANTY3H_HUMANHPRD11359875 6150037 7901013 details
MAPK2_HUMANSRF_HUMANHPRD10318869 10753652 12171911 8413226 details
MAPK2_HUMANBAG2_HUMANHPRD15271996 details
MAPK2_HUMANEF2K_HUMANHPRD12171600 details
MAPK2_HUMANCREB1_HUMANHPRD8887554 details