Entity Details

Primary name DNA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51530
EntryNameDNA2_HUMAN
FullNameDNA replication ATP-dependent helicase/nuclease DNA2
TaxID9606
Evidenceevidence at protein level
Length1060
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDNA2

GO terms

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GOName
GO:0000076 DNA replication checkpoint signaling
GO:0000723 telomere maintenance
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006260 DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006284 base-excision repair
GO:0016887 ATP hydrolysis activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108 5'-flap endonuclease activity
GO:0017116 single-stranded DNA helicase activity
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033567 DNA replication, Okazaki fragment processing
GO:0042645 mitochondrial nucleoid
GO:0043137 DNA replication, removal of RNA primer
GO:0043139 5'-3' DNA helicase activity
GO:0043504 mitochondrial DNA repair
GO:0044806 G-quadruplex DNA unwinding
GO:0045740 positive regulation of DNA replication
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0071932 replication fork reversal
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090656 t-circle formation
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902990 mitotic telomere maintenance via semi-conservative replication

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR014808 DNA replication factor Dna2, N-terminalDomainDomain
IPR026851 DNA replication ATP-dependent helicase/nuclease Dna2FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR041677 DNA2/NAM7 helicase, helicase domainDomainDomain
IPR041679 DNA2/NAM7 helicase-like, C-terminalDomainDomain

Diseases

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