Entity Details

Primary name AAPK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54646
EntryNameAAPK2_HUMAN
FullName5'-AMP-activated protein kinase catalytic subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length552
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPRKAA2

GO terms

Show/Hide Table
GOName
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006853 carnitine shuttle
GO:0007165 signal transduction
GO:0008610 lipid biosynthetic process
GO:0010494 cytoplasmic stress granule
GO:0010508 positive regulation of autophagy
GO:0010629 negative regulation of gene expression
GO:0014850 response to muscle activity
GO:0016055 Wnt signaling pathway
GO:0016236 macroautophagy
GO:0016239 positive regulation of macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016607 nuclear speck
GO:0030424 axon
GO:0030425 dendrite
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0034599 cellular response to oxidative stress
GO:0035174 histone serine kinase activity
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0042149 cellular response to glucose starvation
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0045821 positive regulation of glycolytic process
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 rhythmic process
GO:0050405 [acetyl-CoA carboxylase] kinase activity
GO:0055089 fatty acid homeostasis
GO:0062028 regulation of stress granule assembly
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071277 cellular response to calcium ion
GO:0071333 cellular response to glucose stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903829 positive regulation of cellular protein localization
GO:1904428 negative regulation of tubulin deacetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR028783 PRKAA2, UBA-like autoinhibitory domainDomainDomain
IPR032270 AMPK, C-terminal adenylate sensor domainDomainDomain
IPR039148 5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminalDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

140 interactions

InteractorPartnerSourcesPublicationsLink
AAPK2_HUMANAAKG1_HUMANBioGRID, HPRD, IntAct10698692 17012231 20562859 24981860 25416956 26186194 28514442 31515488 31900314 32296183 9224708 details
AAPK2_HUMANAAKB2_HUMANBioGRID, IntAct17012231 19616115 20562859 24722188 25416956 28514442 31900314 32296183 details
AAPK2_HUMANAAKB1_HUMANBioGRID, HPRD, IntAct20562859 26344197 28514442 31900314 32296183 9224708 details
AAPK2_HUMANAMOT_HUMANBioGRID, IntAct20562859 32296183 details
AAPK2_HUMANKIFC3_HUMANBioGRID, IntAct, MINT21516116 25416956 details
AAPK2_HUMANNECA2_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANGLI1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANITF2_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANTLE5_HUMANBioGRID, IntAct25416956 32296183 details
AAPK2_HUMANAIMP2_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANNONO_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANTRIP6_HUMANBioGRID, HPRD, IntAct16624523 19616115 25416956 details
AAPK2_HUMANKIF24_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANHMBX1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANKCTD1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANNUTM1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANRFX6_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANHOMEZ_HUMANBioGRID, IntAct25416956 32296183 details
AAPK2_HUMANVPS52_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANUSBP1_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANZN397_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANAPBP2_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANZBT8A_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANLMBL3_HUMANBioGRID, IntAct21516116 25416956 32296183 details
AAPK2_HUMANCIP1_HUMANBioGRID, IntAct25416956 31515488 details
AAPK2_HUMANABI2_HUMANBioGRID, IntAct25416956 29892012 32296183 details
AAPK2_HUMANT22D4_HUMANBioGRID, IntAct25416956 details
AAPK2_HUMANLZTS2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANABI1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANZN212_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANAMOL2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANPCH2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANWWP2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSRTD3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCACO2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCACO1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCDR2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANK1C16_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSKIV2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANREL_HUMANBioGRID, IntAct30886144 32296183 details
AAPK2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANGOGA2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANUSH1G_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANAKP8L_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCC172_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSPY1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANKR109_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSOLH1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANGRAP2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANVPS28_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANMOFA1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANAPC11_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANMYCL_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANARRD3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCPSF7_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANRASL3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANPERI_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANKCTD9_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANVP37B_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANTIFA_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANDAAF6_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANIKZF1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANBORG5_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANEMIL1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANGGYF1_HUMANIntAct32296183 details
AAPK2_HUMANNAB2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANDYN2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANMTUS2_HUMANBioGRID, IntAct30886144 32296183 details
AAPK2_HUMANK1328_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCDX4_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANMORN3_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANGOG6A_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSLAP2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANCTAG2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANUSH1C_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANFND3B_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANKI16B_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANPKHN1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANNRBF2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANEPN2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANZSC23_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANAVPI1_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANNGAL_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANPPR32_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANSTAC2_HUMANBioGRID, IntAct32296183 details
AAPK2_HUMANGRN_HUMANIntAct32814053 details
AAPK2_HUMANWFS1_HUMANIntAct32814053 details
AAPK2_HUMANRNF11_HUMANIntAct32814053 details
AAPK2_HUMANEPM2A_HUMANBioGRID18029386 details
AAPK2_HUMANNRAP_HUMANBioGRID19616115 details
AAPK2_HUMANTMOD1_HUMANBioGRID19616115 details
AAPK2_HUMANUBC9_HUMANBioGRID19616115 details
AAPK2_HUMANPBIP1_HUMANBioGRID19616115 details
AAPK2_HUMANSNW1_HUMANBioGRID19616115 details
AAPK2_HUMANMYOZ1_HUMANBioGRID19616115 details
AAPK2_HUMANCS047_HUMANBioGRID19616115 details
AAPK2_HUMANPSD11_HUMANBioGRID19616115 details
AAPK2_HUMANRPTOR_HUMANBioGRID18439900 details
AAPK2_HUMANWWP1_HUMANBioGRID23293026 details
AAPK2_HUMANFOS_HUMANBioGRID25416956 details
AAPK2_HUMANKR103_HUMANBioGRID25416956 details
AAPK2_HUMANNT2NC_HUMANBioGRID25416956 details
AAPK2_HUMANBRCA1_HUMANBioGRID25184681 details
AAPK2_HUMANAP2A_HUMANBioGRID22561688 details
AAPK2_HUMANUBP10_HUMANBioGRID26876938 details
AAPK2_HUMANDNMT1_HUMANBioGRID28143904 details
AAPK2_HUMANRBBP7_HUMANBioGRID28143904 details
AAPK2_HUMANHAT1_HUMANBioGRID28143904 details
AAPK2_HUMANYPEL3_HUMANBioGRID32296183 details
AAPK2_HUMANCCD33_HUMANBioGRID32296183 details
AAPK2_HUMANWASH1_HUMANBioGRID32296183 details
AAPK2_HUMANKRA13_HUMANBioGRID32296183 details
AAPK2_HUMANPRKN_HUMANBioGRID31358971 details
AAPK2_HUMANSYPM_HUMANBioGRID, IntAct20562859 31900314 details
AAPK2_HUMANULK1_HUMANBioGRID, IntAct20562859 21072212 details
AAPK2_HUMANHS90B_HUMANIntAct22939624 details
AAPK2_HUMANSTK11_HUMANBioGRID, HPRD, IntAct10642499 19274086 25241761 details
AAPK2_HUMANDCR1C_HUMANBioGRID, IntAct26186194 28514442 31900314 details
AAPK2_HUMANPRGC1_HUMANDIP17609368 details
AAPK2_HUMANACACA_HUMANBioGRID, HPRD11052978 20562859 2900138 details
AAPK2_HUMANPPARG_HUMANBioGRID18674809 details
AAPK2_HUMANINSR_HUMANBioGRID25687571 details
AAPK2_HUMANPPM1E_HUMANBioGRID20801214 details
AAPK2_HUMANG3BP1_HUMANBioGRID25840010 details
AAPK2_HUMANUBE2O_HUMANBioGRID31900314 details
AAPK2_HUMANENTR1_HUMANBioGRID31900314 details
AAPK2_HUMANF262_HUMANHPRD12853467 1322130 details
AAPK2_HUMANHNF4A_HUMANHPRD12740371 details
AAPK2_HUMANACACB_HUMANHPRD12413941 14532170 14613924 9148944 details
AAPK2_HUMANEF2K_HUMANHPRD11171059 11500364 14709557 15024086 details
AAPK2_HUMANLEP_HUMANHPRD11797013 details