Entity Details

Primary name S12A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55011
EntryNameS12A2_HUMAN
FullNameSolute carrier family 12 member 2
TaxID9606
Evidenceevidence at protein level
Length1212
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSLC12A2

GO terms

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GOName
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0006884 cell volume homeostasis
GO:0006972 hyperosmotic response
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007568 aging
GO:0008511 sodium:potassium:chloride symporter activity
GO:0008519 ammonium transmembrane transporter activity
GO:0009925 basal plasma membrane
GO:0010818 T cell chemotaxis
GO:0015079 potassium ion transmembrane transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0015696 ammonium transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019901 protein kinase binding
GO:0030007 cellular potassium ion homeostasis
GO:0030321 transepithelial chloride transport
GO:0030644 cellular chloride ion homeostasis
GO:0030659 cytoplasmic vesicle membrane
GO:0031253 cell projection membrane
GO:0035633 maintenance of blood-brain barrier
GO:0035725 sodium ion transmembrane transport
GO:0035865 cellular response to potassium ion
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044298 cell body membrane
GO:0045795 positive regulation of cell volume
GO:0046873 metal ion transmembrane transporter activity
GO:0051087 chaperone binding
GO:0051879 Hsp90 protein binding
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0061044 negative regulation of vascular wound healing
GO:0070062 extracellular exosome
GO:0070634 transepithelial ammonium transport
GO:0071944 cell periphery
GO:0098658 inorganic anion import across plasma membrane
GO:0098659 inorganic cation import across plasma membrane
GO:0098719 sodium ion import across plasma membrane
GO:0150003 regulation of spontaneous synaptic transmission
GO:0150104 transport across blood-brain barrier
GO:1902476 chloride transmembrane transport
GO:1903561 extracellular vesicle
GO:1904450 positive regulation of aspartate secretion
GO:1904464 regulation of matrix metallopeptidase secretion
GO:1990573 potassium ion import across plasma membrane
GO:1990869 cellular response to chemokine

Subcellular Location

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Subcellular Location
Basolateral cell membrane

Domains

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DomainNameCategoryType
IPR002443 Solute carrier family 12 member 1/2FamilyFamily
IPR002444 Solute carrier family 12 member 2FamilyFamily
IPR004841 Amino acid permease/ SLC12A domainDomainDomain
IPR004842 SLC12A transporter familyFamilyFamily
IPR013612 Amino acid permease, N-terminalDomainDomain
IPR018491 SLC12A transporter, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00214 TorasemideDrugbanksmall molecule
DB00761 Potassium chlorideDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule
DB01325 QuinethazoneDrugbanksmall molecule
DB11098 Potassium bicarbonateSwissprotsmall molecule