Entity Details

Primary name SOX8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57073
EntryNameSOX8_HUMAN
FullNameTranscription factor SOX-8
TaxID9606
Evidenceevidence at transcript level
Length446
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSOX8

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001755 neural crest cell migration
GO:0002009 morphogenesis of an epithelium
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007422 peripheral nervous system development
GO:0008134 transcription factor binding
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0010817 regulation of hormone levels
GO:0014015 positive regulation of gliogenesis
GO:0014032 neural crest cell development
GO:0033690 positive regulation of osteoblast proliferation
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048469 cell maturation
GO:0048484 enteric nervous system development
GO:0048709 oligodendrocyte differentiation
GO:0060009 Sertoli cell development
GO:0060018 astrocyte fate commitment
GO:0060041 retina development in camera-type eye
GO:0060221 retinal rod cell differentiation
GO:0060612 adipose tissue development
GO:0061138 morphogenesis of a branching epithelium
GO:0072034 renal vesicle induction
GO:0072197 ureter morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0090184 positive regulation of kidney development
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR022151 Sox developmental protein N-terminalDomainDomain
IPR031265 Transcription factor SOX-8FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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