Entity Details

Primary name TIRAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP58753
EntryNameTIRAP_HUMAN
FullNameToll/interleukin-1 receptor domain-containing adapter protein
TaxID9606
Evidenceevidence at protein level
Length221
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesTIRAP

GO terms

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GOName
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005080 protein kinase C binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0030099 myeloid cell differentiation
GO:0030139 endocytic vesicle
GO:0030674 protein-macromolecule adaptor activity
GO:0030890 positive regulation of B cell proliferation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032496 response to lipopolysaccharide
GO:0032587 ruffle membrane
GO:0032648 regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032738 positive regulation of interleukin-15 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, TirapFamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
TIRAP_HUMANMYD88_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11544529 17258210 17583698 18221795 20048342 21334391 24316379 28483816 details
TIRAP_HUMANTIRAP_HUMANBioGRID, HPIDb, IntAct11544529 17258210 24275656 details
TIRAP_HUMANTLR4_HUMANBioGRID, HPRD, IntAct11526399 11544529 17258210 18221795 20048342 21829704 21903422 details
TIRAP_HUMANA4_HUMANBioGRID, IntAct21988832 details
TIRAP_HUMANMPP3_HUMANBioGRID, IntAct21988832 details
TIRAP_HUMANPCNA_HUMANBioGRID, IntAct21988832 details
TIRAP_HUMANLTN1_HUMANBioGRID, IntAct21903422 details
TIRAP_HUMANCCD47_HUMANBioGRID, IntAct21903422 details
TIRAP_HUMANSAMH1_HUMANBioGRID, IntAct21903422 details
TIRAP_HUMANARAF_HUMANBioGRID, IntAct21903422 details
TIRAP_HUMANIRAK1_HUMANBioGRID, IntAct21903422 details
TIRAP_HUMANIRAK4_HUMANBioGRID, IntAct18221795 21903422 details
TIRAP_HUMANCAN1_HUMANInnateDB23023391 details
TIRAP_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
TIRAP_HUMANSARM1_HUMANIntAct26592460 details
TIRAP_HUMANTLR2_HUMANBioGRID, IntAct17258210 18221795 details
TIRAP_HUMANCASP1_HUMANBioGRID, DIP17360653 20048342 details
TIRAP_HUMANTCAM2_HUMANBioGRID, HPRD, IntAct12721283 details
TIRAP_HUMANIRAK2_HUMANBioGRID, HPRD, IntAct11544529 21903422 details
TIRAP_HUMANP85A_HUMANMINT19574958 details
TIRAP_HUMANSTT3A_HUMANIntAct21903422 details
TIRAP_HUMANRAGE_HUMANIntAct21829704 details
TIRAP_HUMANRN216_HUMANBioGRID16968706 details
TIRAP_HUMANSOCS1_HUMANBioGRID, HPRD16415872 29991678 details
TIRAP_HUMANTRAF6_HUMANBioGRID, HPRD15247281 19592497 24084649 details
TIRAP_HUMANBTK_HUMANBioGRID, HPRD12724322 16415872 16439361 details
TIRAP_HUMANKAT2A_HUMANBioGRID23382074 details
TIRAP_HUMANM3K7_HUMANBioGRID24084649 details
TIRAP_HUMANTAB1_HUMANBioGRID24084649 details
TIRAP_HUMANTNFL9_HUMANBioGRID24084649 details
TIRAP_HUMANBCAP_HUMANBioGRID27909057 details
TIRAP_HUMANE2AK2_HUMANHPRD11526399 details
TIRAP_HUMANCD3Z_HUMANHPRD11572860 details
TIRAP_HUMANTRAM1_HUMANHPRD12721283 details
TIRAP_HUMANDNJC3_HUMANHPRD11526399 details
TIRAP_HUMANILRL1_HUMANHPRD15004556 details
TIRAP_HUMANPRKRA_HUMANHPRD11526399 details
TIRAP_HUMANTCAM1_HUMANHPRD14517278 details