Entity Details

Primary name ARP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61158
EntryNameARP3_HUMAN
FullNameActin-related protein 3
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesACTR3

GO terms

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GOName
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0005903 brush border
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0008356 asymmetric cell division
GO:0010592 positive regulation of lamellipodium assembly
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016344 meiotic chromosome movement towards spindle pole
GO:0030027 lamellipodium
GO:0033206 meiotic cytokinesis
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0035861 site of double-strand break
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048013 ephrin receptor signaling pathway
GO:0051653 spindle localization
GO:0060271 cilium assembly
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070358 actin polymerization-dependent cell motility
GO:0071346 cellular response to interferon-gamma

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004000 Actin familyFamilyFamily
IPR015623 Actin-related protein 3FamilyFamily
IPR020902 Actin/actin-like conserved siteSiteConserved site
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamideDrugbanksmall molecule
DB08236 (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-oneDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
ARP3_HUMANWASL_HUMANBioGRID, DIP12732638 17028176 details
ARP3_HUMANWASF2_HUMANBioGRID, HPRD10381382 34079125 9889097 details
ARP3_HUMANUBE3A_HUMANBioGRID26506232 details
ARP3_HUMANJUND_HUMANBioGRID, IntAct20195357 details
ARP3_HUMANHCLS1_HUMANBioGRID12534372 details
ARP3_HUMANSHRPN_HUMANBioGRID28775156 details
ARP3_HUMANSRC8_HUMANBioGRID, HPRD, mbinfo11018051 11231575 12176742 12732638 34079125 details
ARP3_HUMANERPG3_HUMANBioGRID31722399 details
ARP3_HUMANCENPH_HUMANIntAct32814053 details
ARP3_HUMANAPH1A_HUMANIntAct32814053 details
ARP3_HUMANA4_HUMANIntAct32814053 details
ARP3_HUMANWASF3_HUMANBioGRID, HPRD10381382 details
ARP3_HUMANBRPF3_HUMANIntAct32814053 details
ARP3_HUMANWASF1_HUMANBioGRID12829704 34079125 details
ARP3_HUMANUNG_HUMANIntAct32814053 details
ARP3_HUMANCDC42_HUMANBioGRID, HPRD31478661 9860974 details
ARP3_HUMANCH60_HUMANIntAct32814053 details
ARP3_HUMANCHIP_HUMANIntAct32814053 details
ARP3_HUMANERCC6_HUMANBioGRID31722399 details
ARP3_HUMANOGT1_HUMANBioGRID32994395 details
ARP3_HUMANCDK5_HUMANIntAct32814053 details
ARP3_HUMANARPC4_HUMANBioGRID, HPRD, IntAct, MINT11721045 11741539 22863883 22939629 24981860 26344197 28514442 details
ARP3_HUMANARPC5_HUMANBioGRID, DIP, HPRD, IntAct, MINT11741539 22863883 22939629 24981860 26344197 26655834 28514442 34079125 details
ARP3_HUMANARPC3_HUMANBioGRID, HPRD, IntAct11741539 22939629 24981860 26186194 26344197 28514442 details
ARP3_HUMANARC1B_HUMANBioGRID, DIP, IntAct11741539 20404198 20603326 22863883 22939629 24981860 26186194 26344197 26655834 28514442 29568061 details
ARP3_HUMANARPC2_HUMANBioGRID, HPRD, IntAct11721045 11741539 22863883 22939629 24981860 26344197 28514442 details
ARP3_HUMANESR1_HUMANBioGRID, IntAct20308691 21182205 details
ARP3_HUMANARP2_HUMANBioGRID, HPRD, IntAct11721045 11741539 22863883 22939629 24981860 26344197 26496610 28514442 29568061 34079125 details
ARP3_HUMANIDLC_HUMANBioGRID, IntAct27173435 unassigned1312 details
ARP3_HUMANK1C18_HUMANMINT14710194 details
ARP3_HUMANSOX2_HUMANBioGRID21280222 details
ARP3_HUMANTRAF6_HUMANIntAct17353931 details
ARP3_HUMANACTB_HUMANBioGRID20308691 details
ARP3_HUMANEIF3H_HUMANBioGRID32269044 details
ARP3_HUMANLRRK2_HUMANBioGRID20876399 details