Entity Details

Primary name RACK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63244
EntryNameRACK1_HUMAN
FullNameReceptor of activated protein C kinase 1
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesRACK1

GO terms

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GOName
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0003723 RNA binding
GO:0005080 protein kinase C binding
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007369 gastrulation
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010629 negative regulation of gene expression
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0015935 small ribosomal subunit
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030308 negative regulation of cell growth
GO:0030332 cyclin binding
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030496 midbody
GO:0030971 receptor tyrosine kinase binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880 regulation of protein localization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043204 perikaryon
GO:0043547 positive regulation of GTPase activity
GO:0045296 cadherin binding
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051434 BH3 domain binding
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0071333 cellular response to glucose stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0072344 rescue of stalled ribosome
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1990630 IRE1-RACK1-PP2A complex
GO:2000114 regulation of establishment of cell polarity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

168 interactions

InteractorPartnerSourcesPublicationsLink
RACK1_HUMANLRP12_HUMANHPRD, IntAct12809483 details
RACK1_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
RACK1_HUMANGOLM1_HUMANBioGRID, HPRD, IntAct16169070 details
RACK1_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct16169070 details
RACK1_HUMANDD19B_HUMANBioGRID, HPRD, IntAct16169070 details
RACK1_HUMANT22D4_HUMANBioGRID, HPRD, IntAct16189514 details
RACK1_HUMANINAR2_HUMANBioGRID, HPRD, IntAct11046044 11301323 details
RACK1_HUMANDYL1_HUMANBioGRID, IntAct18420585 22863883 details
RACK1_HUMANB2L11_HUMANBioGRID, IntAct18420585 details
RACK1_HUMANACES_HUMANIntAct18194455 details
RACK1_HUMANCSN5_HUMANBioGRID, IntAct18624398 21145461 details
RACK1_HUMANVHL_HUMANBioGRID, I2D20871634 details
RACK1_HUMANADH1B_HUMANBioGRID, IntAct21988832 details
RACK1_HUMANRHOA_HUMANBioGRID, IntAct21988832 details
RACK1_HUMANAURKB_HUMANBioGRID, IntAct21988832 details
RACK1_HUMANLAR4B_HUMANBioGRID, IntAct12388589 21988832 25416956 26186194 28514442 32296183 details
RACK1_HUMANMK06_HUMANBioGRID, MINT21900206 details
RACK1_HUMANBIRC6_HUMANBioGRID, IntAct23414517 details
RACK1_HUMANCHERP_HUMANBioGRID, MINT22365833 details
RACK1_HUMANPRP31_HUMANBioGRID, MINT22365833 details
RACK1_HUMANRED_HUMANBioGRID, MINT22365833 details
RACK1_HUMANWDR83_HUMANBioGRID, MINT22365833 details
RACK1_HUMANESS2_HUMANBioGRID, MINT22365833 details
RACK1_HUMANHNRH2_HUMANBioGRID, MINT22365833 details
RACK1_HUMANPPID_HUMANBioGRID, UniProt21146485 details
RACK1_HUMANKPCB_HUMANBioGRID, HPRD, Molecular Connections10480917 18596232 23866081 24681954 details
RACK1_HUMANRACK1_HUMANBioGRID, HPRD, IntAct17965024 24947010 9442085 details
RACK1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
RACK1_HUMANUBP54_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANCNOT2_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANUBP10_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANBYST_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANMKRN2_HUMANBioGRID, IntAct25416956 32296183 details
RACK1_HUMANDPYL1_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANARRD3_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANGGN_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANGPBP1_HUMANBioGRID, IntAct32296183 details
RACK1_HUMANZSC12_HUMANIntAct32296183 details
RACK1_HUMANACTN2_HUMANBioGRID, IntAct25910212 details
RACK1_HUMANEED_HUMANBioGRID, DIP20080539 details
RACK1_HUMANINCA1_HUMANIntAct21750715 details
RACK1_HUMANPCNA_HUMANUniProt26030842 details
RACK1_HUMANESR1_HUMANBioGRID, IntAct20348541 31527615 details
RACK1_HUMANP63_HUMANBioGRID, IntAct12692135 15467455 details
RACK1_HUMANHABP4_HUMANBioGRID, HPRD14699138 16455055 details
RACK1_HUMANFAN_HUMANBioGRID, HPRD12391233 details
RACK1_HUMANANDR_HUMANBioGRID, HPRD12958311 32814769 details
RACK1_HUMANITB2_HUMANBioGRID, HPRD9442085 details
RACK1_HUMANCCNA1_HUMANBioGRID, HPRD15159402 details
RACK1_HUMANIF6_HUMANBioGRID, HPRD14654845 details
RACK1_HUMANTYK2_HUMANBioGRID, HPRD12960323 details
RACK1_HUMANJAK1_HUMANBioGRID, HPRD12960323 22558273 details
RACK1_HUMANSTAT1_HUMANBioGRID, HPRD11301323 12960323 details
RACK1_HUMANIL4RA_HUMANBioGRID, HPRD12960323 details
RACK1_HUMANIL2RB_HUMANBioGRID, HPRD12960323 details
RACK1_HUMANEPOR_HUMANBioGRID, HPRD12960323 details
RACK1_HUMANP73_HUMANBioGRID, HPRD12761493 details
RACK1_HUMANS27A6_HUMANBioGRID, HPRD16169070 details
RACK1_HUMANGRAP2_HUMANBioGRID, HPRD10820259 details
RACK1_HUMANIL3RB_HUMANBioGRID, HPRD10490850 details
RACK1_HUMANKPCE_HUMANBioGRID, HPRD11709417 11956211 details
RACK1_HUMANPTPRM_HUMANBioGRID, HPRD11278757 11801604 details
RACK1_HUMANPDE4D_HUMANBioGRID, HPRD10329691 11516626 12193273 19372219 details
RACK1_HUMANFYN_HUMANBioGRID, HPRD11943848 12524444 details
RACK1_HUMANPLCG1_HUMANBioGRID, HPRD8290562 details
RACK1_HUMANATRAP_HUMANBioGRID, HPRD11733189 details
RACK1_HUMANSRC_HUMANBioGRID, HPRD11279199 11964397 18596232 9584165 details
RACK1_HUMANRASA1_HUMANBioGRID, HPRD11350068 details
RACK1_HUMANIGF1R_HUMANBioGRID, HPRD11884618 11964397 16382134 20871634 27684187 details
RACK1_HUMANSAT1_HUMANBioGRID17875644 details
RACK1_HUMANHIF1A_HUMANBioGRID17244529 17875644 19251694 23722539 24648344 25204544 25959252 27320910 details
RACK1_HUMANFBXW7_HUMANBioGRID21860413 details
RACK1_HUMANELOC_HUMANBioGRID17244529 19855191 24648344 details
RACK1_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
RACK1_HUMANELOB_HUMANBioGRID17244529 details
RACK1_HUMANAAKB2_HUMANBioGRID19616115 details
RACK1_HUMANGCR_HUMANBioGRID15955845 details
RACK1_HUMANBRCA1_HUMANBioGRID22990118 26831064 30617304 details
RACK1_HUMANADRB2_HUMANBioGRID23798571 24561123 details
RACK1_HUMANTA2R_HUMANBioGRID18088317 details
RACK1_HUMANTADBP_HUMANBioGRID20020773 24825905 details
RACK1_HUMANPTOV1_HUMANBioGRID23455324 details
RACK1_HUMANTRI45_HUMANBioGRID24681954 details
RACK1_HUMANINAR1_HUMANBioGRID, HPRD11301323 12960323 details
RACK1_HUMANMCPH1_HUMANBioGRID29150431 details
RACK1_HUMANST7_HUMANBioGRID, HPRD12809483 details
RACK1_HUMANGATA4_HUMANBioGRID27208796 details
RACK1_HUMANEP300_HUMANBioGRID27208796 details
RACK1_HUMANOLA1_HUMANBioGRID30617304 details
RACK1_HUMANTBG1_HUMANBioGRID30617304 details
RACK1_HUMANNANOG_HUMANBioGRID30809310 details
RACK1_HUMANATG5_HUMANBioGRID27325703 details
RACK1_HUMANPI3R4_HUMANBioGRID24166503 26549445 details
RACK1_HUMANBAKOR_HUMANBioGRID24166503 26549445 details
RACK1_HUMANBECN1_HUMANBioGRID24166503 26549445 details
RACK1_HUMANAAPK1_HUMANBioGRID24166503 26549445 details
RACK1_HUMANTEN1_HUMANBioGRID25648896 details
RACK1_HUMANTM131_HUMANBioGRID32296183 details
RACK1_HUMANSL9A5_HUMANBioGRID16920332 details
RACK1_HUMANPLEC_HUMANHPRD14966116 details
RACK1_HUMANSC6A3_HUMANHPRD15202772 details
RACK1_HUMANNFAC1_HUMANHPRD12521306 details
RACK1_HUMANITB7_HUMANHPRD9765275 details
RACK1_HUMANITB5_HUMANHPRD9442085 details
RACK1_HUMANNEMO_HUMANIntAct14743216 details
RACK1_HUMANADT3_HUMANIntAct16169070 details
RACK1_HUMANAGO2_HUMANMINT21525958 details
RACK1_HUMANPIAS2_HUMANMINT22210188 details
RACK1_HUMANCADH1_HUMANBioGRID, I2D21685945 25468996 details
RACK1_HUMANPHAG1_HUMANMolecular Connections23866081 details
RACK1_HUMANLYN_HUMANMolecular Connections23866081 details
RACK1_HUMANPARK7_HUMANIntAct24947010 details
RACK1_HUMANJUN_HUMANBioGRID, MINT21860413 25609649 details
RACK1_HUMANNSMA2_HUMANBioGRID, DIP20080539 details
RACK1_HUMANFBXW2_HUMANBioGRID, IntAct23651062 details
RACK1_HUMANRS6_HUMANBioGRID, DIP23455324 25901680 29143818 details
RACK1_HUMANRB_HUMANBioGRID, HPRD12761493 details
RACK1_HUMANITB1_HUMANBioGRID12435334 9442085 details
RACK1_HUMANNHRF1_HUMANBioGRID11956211 details
RACK1_HUMANNMDE2_HUMANBioGRID, HPRD12524444 details
RACK1_HUMANKPCA_HUMANBioGRID, HPRD12435334 details
RACK1_HUMANPABP1_HUMANBioGRID, HPRD12388589 details
RACK1_HUMANRASA3_HUMANBioGRID, HPRD11350068 details
RACK1_HUMANOTUB1_HUMANBioGRID18954305 details
RACK1_HUMANH31_HUMANBioGRID20410295 details
RACK1_HUMANH4_HUMANBioGRID20410295 details
RACK1_HUMANFEM1B_HUMANBioGRID19855191 details
RACK1_HUMAN2AAA_HUMANBioGRID18172692 details
RACK1_HUMANTRI18_HUMANBioGRID18172692 details
RACK1_HUMANGBB1_HUMANBioGRID, HPRD12359736 18596232 19917775 22065575 details
RACK1_HUMANGBG2_HUMANBioGRID19917775 22065575 details
RACK1_HUMANCISH_HUMANBioGRID18420585 details
RACK1_HUMANCUL2_HUMANBioGRID18420585 details
RACK1_HUMANKCNA5_HUMANBioGRID22547057 details
RACK1_HUMANKCAB1_HUMANBioGRID22547057 details
RACK1_HUMANAGTR1_HUMANBioGRID18088317 details
RACK1_HUMANSYN2_HUMANBioGRID22558273 details
RACK1_HUMANTRAF6_HUMANBioGRID26038599 details
RACK1_HUMANTNR11_HUMANBioGRID26038599 details
RACK1_HUMANGAN_HUMANBioGRID26460568 details
RACK1_HUMANGLI1_HUMANBioGRID26603838 details
RACK1_HUMANTRAF2_HUMANBioGRID26038599 details
RACK1_HUMANM3K7_HUMANBioGRID26038599 details
RACK1_HUMANMP2K6_HUMANBioGRID26038599 details
RACK1_HUMANU2AF2_HUMANBioGRID26641092 details
RACK1_HUMANAHSA1_HUMANBioGRID22504172 details
RACK1_HUMANDERL1_HUMANBioGRID28137758 details
RACK1_HUMANRSCA1_HUMANBioGRID27555600 details
RACK1_HUMANFBX17_HUMANBioGRID27956528 details
RACK1_HUMANPP2AA_HUMANBioGRID27956528 details
RACK1_HUMANZN598_HUMANBioGRID28685749 details
RACK1_HUMANRHDF1_HUMANBioGRID24648344 details
RACK1_HUMANP85A_HUMANBioGRID11964397 26839216 details
RACK1_HUMANINSR_HUMANBioGRID, HPRD11964397 16382134 details
RACK1_HUMANPTN11_HUMANBioGRID11964397 details
RACK1_HUMANBARD1_HUMANBioGRID30617304 details
RACK1_HUMANMAVS_HUMANBioGRID30527812 details
RACK1_HUMANPK3C3_HUMANBioGRID24166503 26549445 details
RACK1_HUMANSTYK1_HUMANBioGRID31696776 details
RACK1_HUMANSYT1_HUMANHPRD1326322 details
RACK1_HUMANTBB2A_HUMANHPRD12884273 details
RACK1_HUMANTNR1A_HUMANHPRD12391233 details
RACK1_HUMANKPCD_HUMANHPRD11884618 details
RACK1_HUMANKPCD1_HUMANHPRD11884618 details
RACK1_HUMANGBRB3_HUMANHPRD14724252 details
RACK1_HUMANSUMO4_HUMANHPRD16236267 details
RACK1_HUMANSTAT3_HUMANHPRD16382134 details
RACK1_HUMANDYN1_HUMANHPRD12359736 details