Entity Details

Primary name HBA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP69905
EntryNameHBA_HUMAN
FullNameHemoglobin subunit alpha
TaxID9606
Evidenceevidence at protein level
Length142
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHBA1
HBA2

GO terms

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GOName
GO:0005344 oxygen carrier activity
GO:0005506 iron ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0006898 receptor-mediated endocytosis
GO:0010942 positive regulation of cell death
GO:0015671 oxygen transport
GO:0015701 bicarbonate transport
GO:0016020 membrane
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0022627 cytosolic small ribosomal subunit
GO:0031838 haptoglobin-hemoglobin complex
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0043177 organic acid binding
GO:0070062 extracellular exosome
GO:0071682 endocytic vesicle lumen
GO:0072562 blood microparticle
GO:0098869 cellular oxidant detoxification

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000971 GlobinDomainDomain
IPR002338 Haemoglobin, alpha-typeFamilyFamily
IPR002339 Haemoglobin, piFamilyFamily
IPR009050 Globin-like superfamilyFamilyHomologous superfamily
IPR012292 Globin/ProtoglobinFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00893 Iron DextranDrugbanksmall molecule
DB01592 IronDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02126 4-Carboxycinnamic AcidDrugbanksmall molecule
DB06154 Pentaerythritol tetranitrateDrugbanksmall molecule
DB07427 2-[(2-methoxy-5-methylphenoxy)methyl]pyridineDrugbanksmall molecule
DB07428 4-[(5-methoxy-2-methylphenoxy)methyl]pyridineDrugbanksmall molecule
DB07645 Sebacic acidDrugbanksmall molecule
DB08077 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACIDDrugbanksmall molecule
DB08262 2,6-dicarboxynaphthaleneDrugbanksmall molecule
DB08486 EfaproxiralDrugbanksmall molecule
DB08632 Trimesic acidDrugbanksmall molecule
DB09112 Nitrous acidDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09140 OxygenDrugbanksmall molecule
DB09147 Ferric pyrophosphateDrugbanksmall molecule
DB09517 Sodium ferric gluconate complexDrugbanksmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB13995 Ferric pyrophosphate citrateDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule
DB14975 VoxelotorDrugbanksmall molecule
DB15617 Ferric derisomaltoseDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
HBA_HUMANHBG2_HUMANBioGRID, IntAct, MINT32296183 881729 details
HBA_HUMANVAS1_HUMANBioGRID, HPRD, IntAct16169070 details
HBA_HUMANHBB_HUMANBioGRID, DIP, HPRD, IntAct10390349 10930828 11724557 12122004 1552945 15835899 16169070 28665412 29997244 30833564 32296183 6644819 6683087 8980683 9441940 9830011 9894000 details
HBA_HUMANPTEN_HUMANBioGRID, HPRD, IntAct16169070 details
HBA_HUMANNP1L1_HUMANHPRD, IntAct16169070 details
HBA_HUMANAHSP_HUMANDIP, HPRD, IntAct12192002 15550245 25156257 details
HBA_HUMANCATD_HUMANMINT17112520 details
HBA_HUMANTSC1_HUMANIntAct17355907 details
HBA_HUMANDAXX_HUMANBioGRID, IntAct21988832 details
HBA_HUMANUBE3A_HUMANBioGRID, MINT21900206 details
HBA_HUMANHBE_HUMANBioGRID, HPRD, IntAct11159543 32296183 9665850 details
HBA_HUMANCCD57_HUMANBioGRID, IntAct25416956 details
HBA_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
HBA_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
HBA_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
HBA_HUMANHBD_HUMANBioGRID, IntAct32296183 details
HBA_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
HBA_HUMANHBAT_HUMANBioGRID, IntAct32296183 details
HBA_HUMANNOS3_HUMANDIP23123858 details
HBA_HUMANNB5R3_HUMANDIP23123858 details
HBA_HUMANDNJC5_HUMANBioGRID, IntAct29997244 details
HBA_HUMANISK7_HUMANBioGRID12646258 details
HBA_HUMANUCHL5_HUMANBioGRID21800051 details
HBA_HUMANOSTP_HUMANBioGRID22779921 details
HBA_HUMANCRYAB_HUMANBioGRID22815750 details
HBA_HUMANNT2NA_HUMANBioGRID32296183 details
HBA_HUMANHLAB_HUMANIntAct17353931 details
HBA_HUMANCLUS_HUMANBioGRID22016805 details
HBA_HUMANB3AT_HUMANBioGRID22016805 details
HBA_HUMANITA4_HUMANBioGRID22623428 details
HBA_HUMANEGFR_HUMANBioGRID23956138 details
HBA_HUMANCBPM_HUMANHPRD8635221 details
HBA_HUMANHBA_HUMANHPRD1512262 6644819 6726807 details