Entity Details

Primary name ADA17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78536
EntryNameADA17_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 17
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesADAM17

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002446 neutrophil mediated immunity
GO:0002467 germinal center formation
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010820 positive regulation of T cell chemotaxis
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032496 response to lipopolysaccharide
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035624 receptor transactivation
GO:0042493 response to drug
GO:0042987 amyloid precursor protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0046872 metal ion binding
GO:0048536 spleen development
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051272 positive regulation of cellular component movement
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1905564 positive regulation of vascular endothelial cell proliferation

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR032029 ADAM17, membrane-proximal domainDomainDomain
IPR034025 ADAM10/ADAM17 catalytic domainDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06943 (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiolDrugbanksmall molecule
DB07079 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiolDrugbanksmall molecule
DB07121 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDEDrugbanksmall molecule
DB07145 (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDEDrugbanksmall molecule
DB07147 methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylateDrugbanksmall molecule
DB07189 (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acidDrugbanksmall molecule
DB07233 N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophanDrugbanksmall molecule
DB07964 (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDEDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
ADA17_HUMANMD2L1_HUMANBioGRID, HPRD, UniProt10527948 11741929 details
ADA17_HUMANPTN3_HUMANHPRD, MINT12207026 details
ADA17_HUMANDLG1_HUMANBioGRID, HPRD, MINT12668732 18930083 details
ADA17_HUMANPDIA3_HUMANBioGRID, MINT17170699 details
ADA17_HUMANA4_HUMANIntAct9774383 details
ADA17_HUMANJAG1_HUMANIntAct23375636 details
ADA17_HUMANITB1_HUMANIntAct, UniProt22413019 30455686 details
ADA17_HUMANPDPK1_HUMANDIP16641105 details
ADA17_HUMANMK01_HUMANBioGRID12058067 details
ADA17_HUMANTIMP3_HUMANBioGRID, HPRD12044879 details
ADA17_HUMANTNR1A_HUMANBioGRID17010968 details
ADA17_HUMANTNR1B_HUMANBioGRID17010968 details
ADA17_HUMANFHL2_HUMANHPRD16619241 details
ADA17_HUMANTGFA_HUMANBioGRID, HPRD, IntAct11823465 18930083 25241761 details
ADA17_HUMANSRC_HUMANDIP16641105 details
ADA17_HUMANITAV_HUMANUniProt30455686 details
ADA17_HUMANSNX18_HUMANUniProt25036101 details
ADA17_HUMANSNX9_HUMANUniProt25036101 details
ADA17_HUMANSNX33_HUMANUniProt25036101 details
ADA17_HUMANPACN1_HUMANUniProt25036101 details
ADA17_HUMANPACN2_HUMANUniProt25036101 details
ADA17_HUMANPACN3_HUMANUniProt25036101 details
ADA17_HUMANEED_HUMANBioGRID23317503 details
ADA17_HUMANPAXI_HUMANBioGRID23317503 details
ADA17_HUMANNOTC1_HUMANHPRD10882063 9620803 details
ADA17_HUMANTNFA_HUMANHPRD10799478 12135369 details
ADA17_HUMANERBB4_HUMANHPRD15534001 details
ADA17_HUMANMD2L2_HUMANHPRD10527948 details
ADA17_HUMANSH319_HUMANHPRD15280379 details
ADA17_HUMANTNF11_HUMANHPRD10224132 details