Entity Details

Primary name PTN12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05209
EntryNamePTN12_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 12
TaxID9606
Evidenceevidence at protein level
Length780
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN12

GO terms

Show/Hide Table
GOName
GO:0002102 podosome
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006470 protein dephosphorylation
GO:0017124 SH3 domain binding
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0038128 ERBB2 signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042246 tissue regeneration
GO:0042995 cell projection
GO:0071345 cellular response to cytokine stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1901185 negative regulation of ERBB signaling pathway
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012266 Protein-tyrosine phosphatase, non-receptor type-12FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule

Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
PTN12_HUMANPPIP1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11711533 11971877 14707117 32296183 9422760 details
PTN12_HUMANWASP_HUMANHPRD, IntAct, MINT11711533 14707117 15588985 19167335 details
PTN12_HUMANPSG9_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANTHAP2_HUMANBioGRID, MINT15231748 details
PTN12_HUMANGLHA_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANTEX10_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANRBM19_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANZFP2_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANSTX16_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANUTRN_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANCSH1_HUMANBioGRID, MINT15231748 details
PTN12_HUMANCSH2_HUMANBioGRID, MINT15231748 details
PTN12_HUMANIFT20_HUMANBioGRID, MINT15231748 details
PTN12_HUMANBAG6_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANSMAD5_HUMANBioGRID, HPRD, MINT15231748 details
PTN12_HUMANBCAR1_HUMANBioGRID, HPRD, MINT12714323 27880917 8887669 9285683 9748319 9920935 details
PTN12_HUMANCADH2_HUMANIntAct19167335 details
PTN12_HUMANTEC_HUMANIntAct19167335 details
PTN12_HUMANERBB2_HUMANIntAct19167335 21376233 details
PTN12_HUMANPGFRB_HUMANIntAct, MINT12614164 19167335 21376233 details
PTN12_HUMANMET_HUMANIntAct19167335 details
PTN12_HUMANPAXI_HUMANBioGRID, HPRD, IntAct10085298 10400685 10625692 11950600 19167335 27880917 28514442 28675297 34079125 9497381 details
PTN12_HUMANLCK_HUMANIntAct19167335 details
PTN12_HUMANCTNB1_HUMANIntAct19167335 details
PTN12_HUMANINSR_HUMANHPRD, IntAct19167335 8454633 details
PTN12_HUMANGAB1_HUMANIntAct19167335 details
PTN12_HUMANNMDE2_HUMANIntAct19167335 details
PTN12_HUMANNTRK1_HUMANBioGRID, IntAct19167335 25921289 details
PTN12_HUMANNSF_HUMANIntAct19167335 details
PTN12_HUMANPDPK1_HUMANIntAct19167335 details
PTN12_HUMANGHR_HUMANIntAct19167335 details
PTN12_HUMANTIE2_HUMANIntAct19167335 details
PTN12_HUMANACK1_HUMANIntAct19167335 details
PTN12_HUMANSHC1_HUMANBioGRID, HPRD, IntAct, MINT11342545 11432829 12052829 19380743 24189400 24412244 27880917 28514442 28675297 31980649 7929214 8626541 details
PTN12_HUMANEGFR_HUMANBioGRID, IntAct, MINT20029029 21376233 24658140 25402006 28065597 31980649 details
PTN12_HUMANGRB2_HUMANBioGRID, HPRD, IntAct21706016 28675297 9135065 details
PTN12_HUMANAN32B_HUMANBioGRID, MINT24412244 details
PTN12_HUMANFANCC_HUMANBioGRID, MINT24412244 details
PTN12_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
PTN12_HUMANCC180_HUMANBioGRID, MINT24412244 details
PTN12_HUMANCANB2_HUMANBioGRID, MINT24412244 details
PTN12_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
PTN12_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
PTN12_HUMANSTX17_HUMANBioGRID, MINT24412244 details
PTN12_HUMANZN510_HUMANBioGRID, MINT24412244 details
PTN12_HUMANLMTK2_HUMANBioGRID, MINT28065597 details
PTN12_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
PTN12_HUMANERBB4_HUMANBioGRID, MINT28065597 details
PTN12_HUMANERBB3_HUMANBioGRID, MINT28065597 details
PTN12_HUMANROR2_HUMANBioGRID, MINT28065597 details
PTN12_HUMANPTK7_HUMANBioGRID, MINT28065597 details
PTN12_HUMANFGFR2_HUMANBioGRID, MINT28065597 details
PTN12_HUMANFGFR4_HUMANBioGRID, MINT28065597 details
PTN12_HUMANVGFR2_HUMANBioGRID, MINT28065597 details
PTN12_HUMANIGF1R_HUMANBioGRID, MINT28065597 details
PTN12_HUMANCASL_HUMANBioGRID, HPRD9748319 details
PTN12_HUMANEFS_HUMANBioGRID, HPRD9748319 details
PTN12_HUMANTGFI1_HUMANBioGRID, HPRD10092676 details
PTN12_HUMANFAK2_HUMANBioGRID, HPRD11337490 12231407 15588985 details
PTN12_HUMANSRBS2_HUMANBioGRID18559503 details
PTN12_HUMANA4_HUMANBioGRID21244100 21832049 details
PTN12_HUMANCSK_HUMANBioGRID, HPRD11158295 27880917 28675297 details
PTN12_HUMANTEN1_HUMANBioGRID25648896 details
PTN12_HUMANMYCB2_HUMANHPRD15231748 details
PTN12_HUMANKIT_HUMANMINT12614164 details
PTN12_HUMANLPXN_HUMANBioGRID, HPRD, IntAct12674328 28514442 details
PTN12_HUMANPPIP2_HUMANBioGRID, HPRD, IntAct27880917 28514442 28675297 31980649 9804817 details
PTN12_HUMANCASS4_HUMANIntAct31413325 details
PTN12_HUMANDISC1_HUMANIntAct31413325 details
PTN12_HUMANJAK2_HUMANBioGRID, HPRD11731619 details
PTN12_HUMANGELS_HUMANBioGRID11577104 details
PTN12_HUMANWASF1_HUMANBioGRID18559503 details
PTN12_HUMANKPCA_HUMANHPRD7520867 details
PTN12_HUMANABL1_HUMANHPRD11163214 15588985 details
PTN12_HUMANKAPCA_HUMANHPRD7520867 details
PTN12_HUMANFLT3_HUMANHPRD15831474 details