Entity Details

Primary name PAX8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06710
EntryNamePAX8_HUMAN
FullNamePaired box protein Pax-8
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPAX8

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001655 urogenital system development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007417 central nervous system development
GO:0009653 anatomical structure morphogenesis
GO:0030878 thyroid gland development
GO:0039003 pronephric field specification
GO:0042472 inner ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048793 pronephros development
GO:0048856 anatomical structure development
GO:0071371 cellular response to gonadotropin stimulus
GO:0071599 otic vesicle development
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072207 metanephric epithelium development
GO:0072221 metanephric distal convoluted tubule development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001523 Paired domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR022130 Paired-box protein 2 C-terminalDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR043182 Paired DNA-binding domainDomainDomain
IPR043565 PAX familyFamilyFamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
PAX8_HUMANSERC1_HUMANBioGRID, IntAct20195357 details
PAX8_HUMANANXA7_HUMANBioGRID, IntAct20195357 details
PAX8_HUMANIKKA_HUMANBioGRID, IntAct21988832 details
PAX8_HUMANCXCL9_HUMANBioGRID, IntAct21988832 details
PAX8_HUMANKPYM_HUMANBioGRID, IntAct21988832 details
PAX8_HUMANSMAD4_HUMANIntAct27107012 details
PAX8_HUMANHXC9_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANHXC8_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANLONF1_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANSAE1_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANDOK4_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANCDK3_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANGCM2_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANCREST_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
PAX8_HUMANOBF1_HUMANBioGRID, IntAct20211142 details
PAX8_HUMANNKX21_HUMANBioGRID, HPRD12441357 14970209 details
PAX8_HUMANEP300_HUMANBioGRID, HPRD10924503 details
PAX8_HUMANAURKA_HUMANBioGRID31391550 details
PAX8_HUMANSKP2_HUMANBioGRID31391550 details
PAX8_HUMANNUCL_HUMANIntAct20195357 details
PAX8_HUMANCSTN1_HUMANIntAct20195357 details
PAX8_HUMANHS71A_HUMANIntAct20195357 details
PAX8_HUMANHS71B_HUMANIntAct20195357 details
PAX8_HUMANRSBN1_HUMANIntAct20195357 details
PAX8_HUMANTMA16_HUMANIntAct20195357 details
PAX8_HUMANUNK_HUMANIntAct20195357 details
PAX8_HUMANRLA2_HUMANIntAct20195357 details
PAX8_HUMANRB_HUMANBioGRID, I2D21602887 details
PAX8_HUMANSMAD3_HUMANHPRD14623893 details
PAX8_HUMANWBP2_HUMANHPRD14531730 details
PAX8_HUMANID2_HUMANHPRD11134340 details