Entity Details

Primary name BAX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07812
EntryNameBAX_HUMAN
FullNameApoptosis regulator BAX
TaxID9606
Evidenceevidence at protein level
Length192
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesBAX

GO terms

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GOName
GO:0001541 ovarian follicle development
GO:0001764 neuron migration
GO:0001777 T cell homeostatic proliferation
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0002358 B cell homeostatic proliferation
GO:0002904 positive regulation of B cell apoptotic process
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006687 glycosphingolipid metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007281 germ cell development
GO:0008053 mitochondrial fusion
GO:0008289 lipid binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637 apoptotic mitochondrial changes
GO:0009566 fertilization
GO:0009636 response to toxic substance
GO:0009651 response to salt stress
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015267 channel activity
GO:0016020 membrane
GO:0016032 viral process
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0030544 Hsp70 protein binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032091 negative regulation of protein binding
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0032976 release of matrix enzymes from mitochondria
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0035234 ectopic germ cell programmed cell death
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045136 development of secondary sexual characteristics
GO:0046666 retinal cell programmed cell death
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048087 positive regulation of developmental pigmentation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048515 spermatid differentiation
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048678 response to axon injury
GO:0048873 homeostasis of number of cells within a tissue
GO:0051087 chaperone binding
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051402 neuron apoptotic process
GO:0051434 BH3 domain binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0060011 Sertoli cell proliferation
GO:0060041 retina development in camera-type eye
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060068 vagina development
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 extracellular exosome
GO:0070242 thymocyte apoptotic process
GO:0070584 mitochondrion morphogenesis
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097144 BAX complex
GO:0097145 BAK complex
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1990117 B cell receptor apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR026304 Apoptosis regulator BAXFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
BAX_HUMANHUNIN_HUMANHPRD, MINT12732850 details
BAX_HUMANBAX_HUMANBioGRID, DIP, IntAct, MINT10620504 11161816 14963330 1558161 17074758 17289999 17668322 18547146 18835031 19062087 19074440 19767770 20360684 20850011 21712378 22198199 23374347 details
BAX_HUMANBCL2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10620799 10716992 14980220 15231068 15899854 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 21778226 22262057 23479509 24141421 26004684 29749471 32064756 8358790 9111042 9388232 9463381 details
BAX_HUMANB2CL1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11283018 12137781 12853473 14963330 15131699 16151013 17289999 17525735 18547146 18981409 19074440 19427863 21199865 21458670 21567405 21671007 21852238 24814347 25115399 25241761 26186194 26496610 27684187 28202514 28514442 28760928 29749471 32064756 9027312 9111042 9153240 9388232 9742125 9824152 details
BAX_HUMANMCL1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10837489 15077116 17525735 18981409 19148187 19968986 21199865 21458670 21566062 26186194 28514442 details
BAX_HUMANB2L11_HUMANBioGRID, DIP, IntAct, MINT17289999 17525735 18948948 19427863 21199865 23235460 23374347 26186194 details
BAX_HUMANIRF3_HUMANMINT20360684 details
BAX_HUMANB2CL2_HUMANBioGRID, DIP, IntAct10381646 17289999 18981409 21199865 25115399 28514442 details
BAX_HUMANSHLB1_HUMANBioGRID, HPRD, IntAct11161816 11259440 19074440 details
BAX_HUMANERN1_HUMANHPRD, IntAct16645094 details
BAX_HUMANBID_HUMANBioGRID, DIP, HPRD, IntAct15574335 17289999 20956295 23374347 25241761 details
BAX_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
BAX_HUMANP53_HUMANBioGRID, IntAct17906639 25115399 25241761 32064756 details
BAX_HUMANSYUA_HUMANBioGRID, IntAct25241761 32814053 details
BAX_HUMANAN32B_HUMANBioGRID, MINT24412244 details
BAX_HUMANLEF1_HUMANBioGRID, MINT24412244 details
BAX_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
BAX_HUMANAKT1_HUMANMINT26763134 details
BAX_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
BAX_HUMANB2L12_HUMANBioGRID, IntAct26186194 28514442 29749471 details
BAX_HUMANKCNA3_HUMANBioGRID, DIP, HPRD18818304 20114030 details
BAX_HUMANGSK3B_HUMANDIP20080742 details
BAX_HUMANB2LA1_HUMANBioGRID, HPRD10753914 details
BAX_HUMANVDAC1_HUMANBioGRID, HPRD12767928 15637055 28760928 9843949 details
BAX_HUMAN1433T_HUMANBioGRID, HPRD12426317 details
BAX_HUMANADT1_HUMANBioGRID, HPRD9748162 details
BAX_HUMANPARK7_HUMANBioGRID21852238 details
BAX_HUMANCRYA2_HUMANBioGRID14752512 details
BAX_HUMANCRYAA_HUMANBioGRID14752512 details
BAX_HUMANCRYAB_HUMANBioGRID14752512 details
BAX_HUMAN1433B_HUMANBioGRID22785534 details
BAX_HUMANZBT24_HUMANBioGRID19074440 details
BAX_HUMANBBC3B_HUMANHPRD15574335 details
BAX_HUMANBBC3_HUMANHPRD15574335 details
BAX_HUMAN1433S_HUMANHPRD, MINT11574543 details
BAX_HUMANBAK_HUMANBioGRID, HPRD, IntAct, MINT11571294 15901672 16439990 17289999 21712378 details
BAX_HUMANKPCE_HUMANIntAct17668322 details
BAX_HUMANBAD_HUMANBioGRID, MINT17274640 19427863 details
BAX_HUMANR144B_HUMANBioGRID, MINT20300062 details
BAX_HUMANTOM20_HUMANMINT20300062 details
BAX_HUMANUVRAG_HUMANBioGRID, MINT21597469 30686098 details
BAX_HUMANXRCC6_HUMANBioGRID, UniProt15205477 19118032 19177010 19247369 21042904 25299772 details
BAX_HUMANASC_HUMANUniProt14730312 details
BAX_HUMANVRK2_HUMANIntAct23449449 details
BAX_HUMANB2L10_HUMANBioGRID, HPRD, IntAct11278245 23235460 details
BAX_HUMANBOP_HUMANIntAct23055042 details
BAX_HUMANAPR_HUMANBioGRID, HPRD15705586 details
BAX_HUMANCH60_HUMANBioGRID12070120 details
BAX_HUMANMOAP1_HUMANBioGRID, HPRD11060313 details
BAX_HUMANTOM40_HUMANBioGRID17635912 details
BAX_HUMANTOM22_HUMANBioGRID17635912 details
BAX_HUMANPRS6A_HUMANBioGRID20431057 details
BAX_HUMANPRS8_HUMANBioGRID20431057 details
BAX_HUMANHDAC6_HUMANBioGRID21847364 details
BAX_HUMANXRCC5_HUMANBioGRID19177010 details
BAX_HUMANCLUS_HUMANBioGRID16113678 19118032 19177010 21567405 23538443 details
BAX_HUMANXIAP_HUMANBioGRID21712378 details
BAX_HUMANHSP74_HUMANBioGRID15388581 details
BAX_HUMANCASP9_HUMANBioGRID15254227 details
BAX_HUMANCASP8_HUMANBioGRID15254227 details
BAX_HUMANCASP7_HUMANBioGRID15254227 details
BAX_HUMANCASP3_HUMANBioGRID15254227 details
BAX_HUMANCYC_HUMANBioGRID15254227 details
BAX_HUMANGIMA5_HUMANBioGRID16509771 details
BAX_HUMANLRRK2_HUMANBioGRID24991765 details
BAX_HUMANNU5M_HUMANBioGRID25115399 details
BAX_HUMANFGFR1_HUMANBioGRID18022941 details
BAX_HUMANPRKN_HUMANBioGRID28760928 32929329 details
BAX_HUMANMK08_HUMANBioGRID19910452 details
BAX_HUMANITCH_HUMANBioGRID32690868 details
BAX_HUMANNOL3_HUMANHPRD15383280 details
BAX_HUMANPP1A_HUMANHPRD17274640 details