Entity Details

Primary name PP2BA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08209
EntryNamePP2BA_HUMAN
FullNameSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPPP3CA

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0004722 protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007420 brain development
GO:0007568 aging
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016018 cyclosporin A binding
GO:0016311 dephosphorylation
GO:0019897 extrinsic component of plasma membrane
GO:0019899 enzyme binding
GO:0030018 Z disc
GO:0030335 positive regulation of cell migration
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0033555 multicellular organismal response to stress
GO:0035562 negative regulation of chromatin binding
GO:0036057 slit diaphragm
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0048741 skeletal muscle fiber development
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0051592 response to calcium ion
GO:0060079 excitatory postsynaptic potential
GO:0070262 peptidyl-serine dephosphorylation
GO:0071333 cellular response to glucose stimulus
GO:0097720 calcineurin-mediated signaling
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905205 positive regulation of connective tissue replacement

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041751 PP2B, metallophosphatase domainDomainDomain
IPR043360 PP2BFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08231 Myristic acidDrugbanksmall molecule

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
PP2BA_HUMANGRB2_HUMANBioGRID, IntAct, MINT12577067 17474147 21900206 details
PP2BA_HUMANCP074_HUMANBioGRID, HPRD, IntAct16189514 21516116 25416956 32296183 details
PP2BA_HUMANCANB1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11439183 19896943 21516116 22343722 22939629 23468591 24954618 25416956 26186194 26264872 26871637 27880917 28514442 32296183 32814053 8524402 details
PP2BA_HUMANABL1_HUMANIntAct17474147 details
PP2BA_HUMANLASP1_HUMANIntAct22665060 details
PP2BA_HUMANJUN_HUMANBioGRID, MINT17215518 25609649 details
PP2BA_HUMANSHAN2_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANAMPH_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANARMT1_HUMANBioGRID, IntAct26344197 27880917 32296183 details
PP2BA_HUMANTENS4_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANTRI72_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANIP3KB_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANABI2_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANU119A_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANAKAP5_HUMANBioGRID, DIP, HPRD, IntAct22343722 32296183 7528941 9765270 details
PP2BA_HUMANF167A_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANNFAC1_HUMANBioGRID, DIP, IntAct23468591 24954618 28514442 details
PP2BA_HUMANRCAN2_HUMANBioGRID, HPRD, IntAct10861295 12102656 26186194 28514442 details
PP2BA_HUMANRCAN1_HUMANBioGRID, HPRD, IntAct10861295 12063245 23118980 26186194 27880917 28514442 details
PP2BA_HUMANNFAC2_HUMANDIP24954618 details
PP2BA_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANERBB3_HUMANMINT28065597 details
PP2BA_HUMANFGFR4_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANRYK_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANPTK7_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANSODC_HUMANHPRD, IntAct11513882 32814053 details
PP2BA_HUMANCABIN_HUMANBioGRID, HPRD11714752 9655484 details
PP2BA_HUMANMYOZ2_HUMANBioGRID, HPRD11114196 11842093 details
PP2BA_HUMANPSA6_HUMANBioGRID21420386 details
PP2BA_HUMANCSEN_HUMANBioGRID17102134 details
PP2BA_HUMANMARH7_HUMANBioGRID24905733 details
PP2BA_HUMANUBE4B_HUMANBioGRID29326975 details
PP2BA_HUMANKLHL3_HUMANBioGRID30718414 details
PP2BA_HUMANSC6A4_HUMANBioGRID24107951 details
PP2BA_HUMANPLAC8_HUMANBioGRID32296183 details
PP2BA_HUMANCANB2_HUMANBioGRID32296183 details
PP2BA_HUMANSYUA_HUMANBioGRID29409956 details
PP2BA_HUMANOGT1_HUMANBioGRID32994395 details
PP2BA_HUMANCHIP_HUMANBioGRID29326975 details
PP2BA_HUMANUBP14_HUMANMINT19896943 details
PP2BA_HUMANGCR_HUMANIntAct20195357 details
PP2BA_HUMANRXRB_HUMANIntAct20195357 details
PP2BA_HUMANUTRN_HUMANDIP18838687 details
PP2BA_HUMANDISC1_HUMANIntAct31413325 details
PP2BA_HUMANPPIA_HUMANBioGRID12218175 details
PP2BA_HUMANADRB2_HUMANBioGRID9880537 details
PP2BA_HUMANBCL2_HUMANBioGRID, HPRD19706527 7593193 9109491 details
PP2BA_HUMANMYOZ1_HUMANBioGRID11114196 details
PP2BA_HUMANAKT1_HUMANBioGRID20605778 details
PP2BA_HUMANPHLP2_HUMANBioGRID20605778 details
PP2BA_HUMANPTEN_HUMANBioGRID20605778 details
PP2BA_HUMANPDE4D_HUMANBioGRID20647544 details
PP2BA_HUMANTRAF3_HUMANBioGRID22715070 details
PP2BA_HUMANCRTC2_HUMANBioGRID, HPRD15454081 27990298 details
PP2BA_HUMANPP2BA_HUMANHPRD12574411 details
PP2BA_HUMANGBRA1_HUMANHPRD12574411 details
PP2BA_HUMANGBRG2_HUMANHPRD12574411 details
PP2BA_HUMANKPCZ_HUMANHPRD12021260 details
PP2BA_HUMANFKB1A_HUMANHPRD7543369 8524402 details
PP2BA_HUMANGBRB2_HUMANHPRD12574411 details
PP2BA_HUMANCASP3_HUMANHPRD11478781 details
PP2BA_HUMANFKBP8_HUMANHPRD12510191 15757646 details
PP2BA_HUMANSYNJ1_HUMANHPRD14704270 details
PP2BA_HUMANMYOZ3_HUMANHPRD11842093 details
PP2BA_HUMANBAD_HUMANHPRD10195903 details
PP2BA_HUMANAT2B4_HUMANHPRD15955804 details