Entity Details

Primary name ITK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08881
EntryNameITK_HUMAN
FullNameTyrosine-protein kinase ITK/TSK
TaxID9606
Evidenceevidence at protein level
Length620
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesITK

GO terms

Show/Hide Table
GOName
GO:0001819 positive regulation of cytokine production
GO:0001865 NK T cell differentiation
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0035556 intracellular signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042110 T cell activation
GO:0046629 gamma-delta T cell activation
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035583 Tyrosine-protein kinase ITK, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR042785 Tyrosine-protein kinase ITK/TSK, catalytic domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
ITK_HUMANLCP2_HUMANBioGRID, DIP, HPRD, MINT10556826 10636929 12190313 15388330 17420479 21725281 details
ITK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
ITK_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
ITK_HUMANSPR2A_HUMANBioGRID, MINT18155796 details
ITK_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
ITK_HUMANABI1_HUMANMINT20598684 details
ITK_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
ITK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
ITK_HUMANMET_HUMANBioGRID, IntAct24728074 details
ITK_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
ITK_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD8810341 8892607 details
ITK_HUMANADA15_HUMANUniProt25825872 details
ITK_HUMANIMA1_HUMANBioGRID, HPRD11581171 details
ITK_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
ITK_HUMANPPIA_HUMANBioGRID, HPRD11830645 details
ITK_HUMANLAT_HUMANBioGRID, HPRD10506192 12186560 details
ITK_HUMANPLCG1_HUMANBioGRID, HPRD10586033 12163161 details
ITK_HUMANFYN_HUMANBioGRID, HPRD10636929 8810341 details
ITK_HUMANSRC_HUMANBioGRID10636929 details
ITK_HUMANGRB2_HUMANBioGRID, HPRD10636929 8985255 details
ITK_HUMANKHDR1_HUMANBioGRID, HPRD12163161 22745667 8810341 8985255 details
ITK_HUMANITK_HUMANBioGRID, HPRD12163161 17192257 7567982 9820515 details
ITK_HUMANHNRPK_HUMANBioGRID, HPRD8810341 details
ITK_HUMANCBL_HUMANBioGRID, HPRD8810341 details
ITK_HUMANFGFR1_HUMANBioGRID22974441 details
ITK_HUMANDOK1_HUMANBioGRID22974441 details
ITK_HUMANSMUF1_HUMANBioGRID20804422 details
ITK_HUMANERBB4_HUMANBioGRID22973453 details
ITK_HUMANSH22A_HUMANHPRD10587356 details
ITK_HUMANG3BP1_HUMANMINT15743820 details
ITK_HUMANHS90B_HUMANBioGRID, IntAct22939624 28514442 details
ITK_HUMANADA10_HUMANUniProt25036101 details
ITK_HUMANCD2_HUMANBioGRID9677430 details
ITK_HUMANIBTK_HUMANBioGRID18596081 details
ITK_HUMANHS90A_HUMANBioGRID22939624 details
ITK_HUMANP85A_HUMANBioGRID9820515 details
ITK_HUMANCD28_HUMANHPRD10586033 15144186 8992971 details
ITK_HUMANBMX_HUMANHPRD12573241 details
ITK_HUMANBTK_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
ITK_HUMANBLNK_HUMANHPRD10556826 details
ITK_HUMANSMAD4_HUMANHPRD15761153 details
ITK_HUMANTGFR1_HUMANHPRD15761153 details
ITK_HUMANPLCG2_HUMANHPRD15184383 details
ITK_HUMANLCK_HUMANHPRD15144186 9312162 details