Entity Details

Primary name ARHG5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12774
EntryNameARHG5_HUMAN
FullNameRho guanine nucleotide exchange factor 5
TaxID9606
Evidenceevidence at protein level
Length1597
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesARHGEF5

GO terms

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GOName
GO:0002102 podosome
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008289 lipid binding
GO:0030054 cell junction
GO:0032956 regulation of actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0042995 cell projection
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051493 regulation of cytoskeleton organization
GO:0051496 positive regulation of stress fiber assembly
GO:0071944 cell periphery
GO:0090630 activation of GTPase activity
GO:1904591 positive regulation of protein import

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR029212 Rho guanine nucleotide exchange factor 5/35, N-terminalDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ARHG5_HUMANRHOA_HUMANBioGRID, IntAct12006984 32203420 details
ARHG5_HUMANMED28_HUMANBioGRID, MINT16964398 details
ARHG5_HUMANCCNE1_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANCRKL_HUMANBioGRID, IntAct21988832 32203420 details
ARHG5_HUMANGRB2_HUMANBioGRID, IntAct21988832 24189400 31980649 32203420 details
ARHG5_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANSPS2_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANFKBP8_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANAT131_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANCHSS2_HUMANBioGRID, IntAct21988832 details
ARHG5_HUMANTRI27_HUMANBioGRID, IntAct25416956 32296183 details
ARHG5_HUMANCACO2_HUMANBioGRID, IntAct25416956 details
ARHG5_HUMANEFHC2_HUMANBioGRID, IntAct21516116 25416956 32296183 details
ARHG5_HUMANHBAP1_HUMANBioGRID, IntAct25416956 32296183 details
ARHG5_HUMANTRI54_HUMANBioGRID, IntAct25416956 32296183 details
ARHG5_HUMANCOG6_HUMANBioGRID, IntAct27107012 32296183 details
ARHG5_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANPKHG4_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANITF2_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANLRAT1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANRPAC1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANTBC13_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANM21D2_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANSLAI1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANRBTN2_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANEPMIP_HUMANBioGRID, IntAct32296183 details
ARHG5_HUMANA4_HUMANBioGRID21832049 details
ARHG5_HUMAN1433S_HUMANBioGRID, MINT15778465 details
ARHG5_HUMANEGFR_HUMANBioGRID23956138 25754235 details
ARHG5_HUMANPLCG1_HUMANHPRD9314836 details